Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner (Q27664044)

ORCID Public Data File 2021

author name string

Jasmin Strotmeier

1

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Kwangkook Lee

2

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Anne K Völker

3

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Stefan Mahrhold

4

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Yinong Zong

5

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Johannes Zeiser

6

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Jie Zhou

7

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Andreas Pich

8

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Hans Bigalke

9

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Thomas Binz

10

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Rongsheng Jin

Crystal structure of botulinum neurotoxin type A and implications for toxicity

12

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language of work or name

English

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publication date

15 October 2010

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published in

Biochemical Journal

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volume

431

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issue

2

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page(s)

207-16

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cites work

1 reference

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation

21 April 2017

1 reference

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

21 April 2017

1 reference

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

21 April 2017

1 reference

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

21 April 2017

1 reference

Structural Analysis of Botulinum Neurotoxin Type G Receptor Binding,

21 April 2017

1 reference

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

21 April 2017

1 reference

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin

21 April 2017

1 reference

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

21 April 2017

1 reference

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

21 April 2017

1 reference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding

21 April 2017

1 reference

Phasercrystallographic software

21 April 2017

1 reference

Refinement of macromolecular structures by the maximum-likelihood method

21 April 2017

1 reference

Coot: model-building tools for molecular graphics

21 April 2017

1 reference

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

21 April 2017

1 reference

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

21 April 2017

1 reference

Dali server: conservation mapping in 3D

21 April 2017

1 reference

Gangliosides as High Affinity Receptors for Tetanus Neurotoxin

21 April 2017

1 reference

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

21 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Receptor and substrate interactions of clostridial neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Cell entry strategy of clostridial neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Single molecule detection of intermediates during botulinum neurotoxin translocation across membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Glycosphingolipids-sweets for botulinum neurotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

SV2 is the protein receptor for botulinum neurotoxin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2/GT1b complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Molecular basis for tetanus toxin coreceptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

How do tetanus and botulinum toxins bind to neuronal membranes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Nucleotide sequence of the gene encoding Clostridium botulinum neurotoxin type D

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042

Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101042