Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase (Q27664423)

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English	Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase	scientific article

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scholarly article

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13 February 2020

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase (English)

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13 February 2020

organic chemistry

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clinical chemistry

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Pavel Martásek

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13 February 2020

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Fengtian Xue

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13 February 2020

Huiying Li

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13 February 2020

Jianguo Fang

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13 February 2020

Linda J Roman

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13 February 2020

Thomas L Poulos

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13 February 2020

Richard B Silverman

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13 February 2020

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26 August 2010

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13 February 2020

Bioorganic & Medicinal Chemistry Letters

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13 February 2020

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13 February 2020

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13 February 2020

6258-6261

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13 February 2020

Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952696

20 March 2017

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

1 reference

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20 March 2017

The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis

1 reference

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20 March 2017

Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

1 reference

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20 March 2017

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

2 references

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20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952696

29 September 2017

Nitric oxide synthases: structure, function and inhibition

1 reference

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20 March 2017

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952696

29 September 2017

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability

1 reference

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29 September 2017

Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases

1 reference

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29 September 2017

Role of nitric oxide in Parkinson's disease

1 reference

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29 September 2017

Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design

1 reference

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29 September 2017

Nitric oxide synthase inhibitors for the treatment of chronic tension-type headache

1 reference

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Mitochondrial contributions to tissue damage in stroke

1 reference

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29 September 2017

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

1 reference

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29 September 2017

Decreased neuronal nitric oxide synthase messenger RNA and somatostatin messenger RNA in the striatum of Huntington's disease

1 reference

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2 June 2018

Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2952696

27 November 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

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12 December 2020

based on heuristic

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[25] Nitric-oxide synthase assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/20833542

12 December 2020

based on heuristic

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Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20833542

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of isoform-selective inhibitors of nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20833542

12 December 2020

based on heuristic

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Identifiers

10.1016/J.BMCL.2010.08.096

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13 February 2020

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13 February 2020

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13 February 2020

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