In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi (Q27664609)

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scientific article published on September 14, 2010

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi

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English	In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi	scientific article published on September 14, 2010	In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi

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scholarly article

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In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi (English)

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infectious disease

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Trypanosoma cruzi

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James H McKerrow

6

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James H McKerrow

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Yen Ting Chen

1

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Elizabeth Hansell

4

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Linda S. Brinen

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

Iain D. Kerr

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

Patricia S. Doyle

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

William R. Roush

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

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14 September 2010

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full work available at URL

https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000825&type=printable

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856868/pdf/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856868/?tool=EBI

online access status

content deliverer

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

https://europepmc.org/articles/PMC2939063

online access status

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

https://europepmc.org/articles/PMC2939063?pdf=render

Portable Document Format

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content deliverer

Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856868

17 July 2024

http://dx.plos.org/10.1371/journal.pntd.0000825

1 reference

10.1371/JOURNAL.PNTD.0000825

https://api.crossref.org/works/10.1371/JOURNAL.PNTD.0000825

17 July 2024

PLoS Neglected Tropical Diseases

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4

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9

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e825

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Creative Commons Attribution 4.0 International

14 September 2010

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April 2022 Public Data File from Crossref

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Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

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20 March 2017

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases

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Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

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A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

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Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

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29 September 2017

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

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29 September 2017

Michael acceptors as cysteine protease inhibitors.

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29 September 2017

Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model

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29 September 2017

Thiol proteases: inhibitors and potential therapeutic targets

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29 September 2017

Progresses in the field of drug design to combat tropical protozoan parasitic diseases

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29 September 2017

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

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29 September 2017

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29 September 2017

Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

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29 September 2017

A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes

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29 September 2017

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei

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29 September 2017

Recent advances in the synthesis, design and selection of cysteine protease inhibitors

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29 September 2017

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

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29 September 2017

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain

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29 September 2017

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Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors

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Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

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Synthesis of Peptide Isocyanates and Isothiocyanates

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5 Theoretical and practical aspects of proteinase inhibition kinetics

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12 December 2020

based on heuristic

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10.1371/JOURNAL.PNTD.0000825

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