An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA (Q27664845)

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24 July 2024

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9

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Hans J. Gaus

6

object named as

Hans Gaus

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24 July 2024

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Eric E. Swayze

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24 July 2024

author name string

Andres Berdeja

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Andrew Siwkowski

4

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Punit P. Seth

1

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24 July 2024

Charles R. Allerson

2

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Pradeep S. Pallan

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Thazha P. Prakash

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Andrew T. Watt

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full work available at URL

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English

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publication date

27 October 2010

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open access

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20886816/?tool=EBI

24 July 2024

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https://europepmc.org/articles/PMC2993159

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https://doi.org/10.1021/ja105875e

24 July 2024

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open access

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https://pubs.acs.org/doi/pdf/10.1021/ja105875e

24 July 2024

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Journal of the American Chemical Society

24 July 2024

published in

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volume

132

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issue

42

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page(s)

14942-50

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Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models

29 September 2017

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Synthesis of functionalized carbocyclic locked nucleic acid analogues by ring-closing diene and enyne metathesis and their influence on nucleic acid stability and structure.

29 September 2017

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29 September 2017

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

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An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models

29 September 2017

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Design, synthesis, and properties of 2',4'-BNA(NC): a bridged nucleic acid analogue

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29 September 2017

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29 September 2017

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29 September 2017

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An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

2 June 2018

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Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

2 June 2018

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27 November 2018

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Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.

27 November 2018

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Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.

27 November 2018

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On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide

27 November 2018

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27 November 2018

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The First Radical Method for the Introduction of an Ethynyl Group Using a Silicon Tether and Its Application to the Synthesis of 2‘-Deoxy-2‘-C-ethynylnucleosides1

27 November 2018

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Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

27 November 2018

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Five- and Six-Membered Conformationally Locked 2‘,4‘-Carbocyclicribo-Thymidines: Synthesis, Structure, and Biochemical Studies

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An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models

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Synthesis of Conformationally Locked Carba-LNAs through Intramolecular Free-Radical Addition to C═N. Electrostatic and Steric Implication of the Carba-LNA Substituents in the Modified Oligos for Nuclease and Thermodynamic Stabilities

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Synthesis of pyrimidine 2'-deoxy ribonucleosides branched at the 2'-position via radical atom-transfer cyclization reaction with a vinylsilyl group as a radical-acceptor tether

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New stereocontrolled synthesis of isomeric C-branched-β-D-nucleosides by intramolecular free-radical cyclization- opening reactions based on temporary silicon connection

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29

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24 July 2024

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A synthetic method for formyl→ethynyl conversion (RCHO→RCCH or RCCR′)

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Use of 1,2-dichloro 4,5-dicyanoquinone (DDQ) for cleavage of the 2-naphthylmethyl (NAP) group

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45

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48

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24 July 2024

Identifiers

DOI

10.1021/JA105875E

1 reference

1 reference

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