Dynamics connect substrate recognition to catalysis in protein kinase A (Q27664877)

2

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Tao Yu

3

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Marco Tonelli

4

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Alexandr Kornev

5

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Susan S Taylor

6

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Gianluigi Veglia

A conserved protonation-dependent switch controls drug binding in the Abl kinase

7

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publication date

November 2010

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published in

Nature Chemical Biology

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volume

6

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issue

11

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page(s)

821-8

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cites work

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PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

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Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding

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Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

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Multiple conformational changes in enzyme catalysis

20 March 2017

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At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?

20 March 2017

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How enzymes work: analysis by modern rate theory and computer simulations

20 March 2017

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Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease

20 March 2017

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The role of dynamic conformational ensembles in biomolecular recognition

7 April 2017

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A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

7 April 2017

1 reference

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The role of conformational entropy in molecular recognition by calmodulin

7 April 2017

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Defining the conserved internal architecture of a protein kinase.

29 September 2017

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Backbone NMR resonance assignment of the catalytic subunit of cAMP-dependent protein kinase A in complex with AMP-PNP.

29 September 2017

1 reference

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Enzymatic transition states and dynamic motion in barrier crossing

29 September 2017

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Dynamically driven ligand selectivity in cyclic nucleotide binding domains

29 September 2017

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Sending signals dynamically

29 September 2017

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Ligand-induced global transitions in the catalytic domain of protein kinase A.

29 September 2017

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Expression and purification of isotopically labeled peptide inhibitors and substrates of cAMP-dependant protein kinase A for NMR analysis

29 September 2017

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Estimation of the available free energy in a LOV2-J alpha photoswitch

29 September 2017

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NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists

29 September 2017

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Allosteric cooperativity in protein kinase A.

29 September 2017

1 reference

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Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase

29 September 2017

1 reference

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Dynamically driven protein allostery.

29 September 2017

1 reference

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Relating protein motion to catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Fast time scale dynamics of protein backbones: NMR relaxation methods, applications, and functional consequences

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

The changing landscape of protein allostery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

PKA: a portrait of protein kinase dynamics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Physiological substrates of cAMP-dependent protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Kinetic and catalytic mechanisms of protein kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Dynamics of cAMP-dependent protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Strategies for macromolecular synchrotron crystallography.

29 September 2017

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Folding and binding cascades: dynamic landscapes and population shifts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Multiple pathway signal transduction by the cAMP-dependent protein kinase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Conservation of mus-ms enzyme motions in the apo- and substrate-mimicked state

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Dynamic activation of an allosteric regulatory protein.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Mapping chemical exchange in proteins with MW > 50 kD.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3487389

Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields

27 November 2018

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12 December 2020

Flexibility and conformational entropy in protein-protein binding

1 reference

12 December 2020

Solution NMR and computer simulation studies of active site loop motion in triosephosphate isomerase

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12 December 2020

"Unraveling the tail" of how SRPK1 phosphorylates ASF/SF2

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.452

1 reference

Dimensions Publication ID

4457905

1050522209

0 references

Fatcat ID

release_kdocsl5kn5fhjcl3t3fclu5wd4

0 references

4457905

1 reference

1 reference

1 reference