Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design (Q27665912)

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English	Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design	scientific article

Statements

scholarly article

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Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design (English)

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allosteric inhibitor

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based on heuristic

inferred from title

Kunchithapadam Swaminathan

9

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author name string

Suguna Badireddy

1

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Gao Yunfeng

2

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Mark Ritchie

3

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Pearl Akamine

4

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Jian Wu

5

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Choel W Kim

6

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Susan S Taylor

7

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Lin Qingsong

8

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Ganesh S Anand

10

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publication date

March 2011

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Molecular & Cellular Proteomics

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10

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3

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M110.004390

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High-speed and high-resolution UPLC separation at zero degrees Celsius

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20 March 2017

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

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20 March 2017

Structure and regulation of the cAMP-binding domains of Epac2

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20 March 2017

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

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20 March 2017

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20 March 2017

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20 March 2017

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA

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20 March 2017

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7 April 2017

Rational design of inhibitors that bind to inactive kinase conformations

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7 April 2017

Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase.

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29 September 2017

Label-free quantitative proteomics analysis of etiolated maize seedling leaves during greening

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29 September 2017

Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures

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29 September 2017

The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS.

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29 September 2017

Capturing cyclic nucleotides in action: snapshots from crystallographic studies

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29 September 2017

cAMP activation of PKA defines an ancient signaling mechanism.

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29 September 2017

Semi-automated data processing of hydrogen exchange mass spectra using HX-Express

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29 September 2017

Evidence for macromolecular protein rings in the absence of bulk water.

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29 September 2017

The cAMP binding domain: an ancient signaling module

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29 September 2017

Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A.

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29 September 2017

The essential role of RI alpha in the maintenance of regulated PKA activity

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29 September 2017

Cyclic nucleotide analogs as biochemical tools and prospective drugs

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29 September 2017

Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit

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29 September 2017

Mechanism and function of cAMP- and cGMP-dependent protein kinases

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29 September 2017

Bond order and charge localization in nucleoside phosphorothioates

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29 September 2017

Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A.

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29 September 2017

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues

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29 September 2017

Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047156

2 June 2018

Structural dynamics in the activation of Epac.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3047156

27 November 2018

Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics.

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27 November 2018

A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain.

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27 November 2018

Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

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27 November 2018

A novel precursor ion discovery method on a hybrid quadrupole orthogonal acceleration time-of-flight (Q-TOF) mass spectrometer for studying protein phosphorylation.

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27 November 2018

Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states.

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27 November 2018

8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II

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12 December 2020

based on heuristic

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Quantitative proteomic analysis by accurate mass retention time pairs

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https://pubmed.ncbi.nlm.nih.gov/21081668

12 December 2020

based on heuristic

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Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081668

12 December 2020

based on heuristic

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Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ion mobility–mass spectrometry analysis of large protein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pseudosubstrate sequences alone are not sufficient for potent autoinhibition of cAMP- and cGMP-dependent protein kinases as determined by synthetic peptide analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21081668

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/MCP.M110.004390

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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