Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41 (Q27666159)

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English	Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41	scientific article

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Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41 (English)

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crystal structure

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based on heuristic

inferred from title

monoclonal antibody

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based on heuristic

inferred from title

Antonio Lanzavecchia

14

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Federica Sallusto

12

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Gabriella Scarlatti

object named as

Gabriella Scarlatti

11

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10

object named as

Lara Mainetti

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8

object named as

Gloria Agatic

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Fabrizia Vanzetta

7

object named as

Fabrizia Vanzetta

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2

object named as

Davide Corti

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author name string

Charles Sabin

1

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Victor Buzon

3

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Mike S Seaman

4

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David Lutje Hulsik

5

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Andreas Hinz

6

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Chiara Silacci

9

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Robin Weiss

13

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Winfried Weissenhorn

15

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publication date

18 November 2010

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6

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11

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e1001195

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copyright license

Creative Commons Attribution 4.0 International

18 November 2010

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April 2022 Public Data File from Crossref

copyright status

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Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions

1 reference

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HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes

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Viral membrane fusion

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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

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Short constrained peptides that inhibit HIV-1 entry

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Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

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Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues

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Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

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Atomic structure of the ectodomain from HIV-1 gp41

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Core structure of gp41 from the HIV envelope glycoprotein

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Phasercrystallographic software

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Scaling and assessment of data quality

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Refinement of macromolecular structures by the maximum-likelihood method

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Automated protein model building combined with iterative structure refinement

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Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

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A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

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Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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Structure of a V3-containing HIV-1 gp120 core

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7 April 2017

Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

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Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

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Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

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Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

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Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 [...]

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International network for comparison of HIV neutralization assays: the NeutNet report

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Short communication: In vitro synergy between peptides or neutralizing antibodies targeting the N- and C-terminal heptad repeats of HIV Type 1 gp41.

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Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice

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Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

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A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.

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Virus membrane fusion

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Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41

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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

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Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion

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Identifiers

10.1371/JOURNAL.PPAT.1001195

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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OpenCitations bibliographic resource ID

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