A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability (Q27666366)

1

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Yanqi Chang

2

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Mala Samaranayake

3

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Anup K Upadhyay

4

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John R Horton

5

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George R Feehery

6

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Xiaodong Cheng

7

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Sriharsa Pradhan

Nature Structural & Molecular Biology

8

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publication date

January 2011

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published in

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volume

18

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issue

1

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page(s)

42-8

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cites work

Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit

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Lysine acetylation: codified crosstalk with other posttranslational modifications

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A quantitative atlas of mitotic phosphorylation

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Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

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p53 is regulated by the lysine demethylase LSD1

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Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

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Structural basis for the methylation site specificity of SET7/9

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Regulation of p53 activity through lysine methylation

20 March 2017

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The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity

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Translating the Histone Code

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

20 March 2017

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Mechanism of activation of protein kinase B by insulin and IGF-1

20 March 2017

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Chromatin modifications and their function

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The language of covalent histone modifications

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Arginine methylation regulates the p53 response

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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

20 March 2017

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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

20 March 2017

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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

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Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

20 March 2017

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Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

22 April 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

22 April 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

22 April 2017

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A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

22 April 2017

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells

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Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription

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Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

29 September 2017

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Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells

29 September 2017

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Role of phosphorylation in the mammalian circadian clock

29 September 2017

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Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

29 September 2017

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Sequence specificity and role of proximal amino acids of the histone H3 tail on catalysis of murine G9A lysine 9 histone H3 methyltransferase.

29 September 2017

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Phosphorylation of serine-10 of histone H3 shields modified lysine-9 selectively during mitosis

21 January 2018

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Binary switches and modification cassettes in histone biology and beyond.

21 January 2018

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Allosteric Activator Domain of Maintenance Human DNA (Cytosine-5) Methyltransferase and Its Role in Methylation Spreading

21 January 2018

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Multiparametric scaling of diffraction intensities

21 January 2018

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Protein methylation: a signal event in post-translational modification

21 January 2018

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Talk is cheap--cross-talk in establishment, maintenance, and readout of chromatin modifications

31 March 2020

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DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements

31 March 2020

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Implementation of molecular replacement in AMoRe

31 March 2020

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31 March 2020

Glutamyl endopeptidases

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31 March 2020

Identifiers

DOI

10.1038/NSMB.1939

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Dimensions Publication ID

4098785

1029600804

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Fatcat ID

release_zzfaossypvg4von2ehcu3msgiy

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4098785

1 reference

1 reference

1 reference