Structural basis for the cyclophilin A binding affinity and immunosuppressive potency ofE-ISA247 (voclosporin) (Q27666620)

2

0 references

Eric Kusznir

3

0 references

Bernard Gsell

4

0 references

Martine Stihle

5

0 references

Ralf Thoma

6

0 references

Joerg Benz

7

0 references

Launa Aspeslet

8

0 references

Derrick Freitag

9

0 references

Michael Hennig

Acta Crystallographica Section D: Biological Crystallography

10

0 references

publication date

February 2011

0 references

published in

0 references

volume

67

0 references

issue

Pt 2

0 references

page(s)

119-23

0 references

cites work

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Molecular replacement with MOLREP

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

ISAtx-247 (Isotechnika/Roche).

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Biochemical mechanisms of cyclosporine neurotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Cyclosporine: 20 years of experience at the University of Munich.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Systemic therapies for psoriasis: understanding current and newly emerging therapies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Cyclosporine nephrotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Molecular actions of calcineurin inhibitors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Structures of cyclophilin-ligand complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Fluorescence methods for studying equilibrium macromolecule-ligand interactions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Renal biopsy findings in long-term cyclosporin treatment of psoriasis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

The novel calcineurin inhibitor ISA247: a more potent immunosuppressant than cyclosporine in vitro.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

SPR-based interaction studies with small molecular weight ligands using hAGT fusion proteins

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate model

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Amelioration of accelerated collagen induced arthritis by a novel calcineurin inhibitor, ISA(TX)247.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

ISA(TX)247: a novel calcineurin inhibitor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

The Molecular Replacement Solution and X-ray Refinement to 2.8 Å of a Decameric Complex of Human Cyclophilin A with the Immunosuppressive Drug Cyclosporin A

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3045272

Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245533

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Correction for light absorption in fluorescence studies of protein-ligand interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245533

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21245533