An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes (Q27670926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

0 references

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

Annaleise R. Howard-Jones

9 February 2020

4

object named as

Annaleise R Howard-Jones

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

5

Christopher T Walsh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Peter J Goldman

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Katherine S Ryan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Michael J Hamill

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Catherine L Drennan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

publication date

1 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

published in

Chemistry and Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

855-865

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

PHENIX: a comprehensive Python-based system for macromolecular structure solution

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction † , ‡

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Combinatorial biosynthesis of antitumor indolocarbazole compounds

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

The mobile flavin of 4-OH benzoate hydroxylase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Features and development of Coot

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Version 1.2 of the Crystallography and NMR system

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

A phase I study of rebeccamycin analog in combination with oxaliplatin in patients with refractory solid tumors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Phase II and pharmacokinetic trial of rebeccamycin analog in advanced biliary cancers.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Divergent pathways in the biosynthesis of bisindole natural products

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Crystallography gets the jump on the enzymologists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Genetic organization of the biosynthetic gene cluster for the indolocarbazole K-252a in Nonomuraea longicatena JCM 11136.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Changes in the catalytic properties of p-hydroxybenzoate hydroxylase caused by the mutation Asn300Asp

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Rebeccamycin and staurosporine biosynthesis: insight into the mechanisms of the flavin-dependent monooxygenases RebC and StaC.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

A His-tag based immobilization method for the preparation and reconstitution of apoflavoproteins.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Reliable quality-control methods for protein crystal structures

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437190

Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840773

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.05.016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22840773

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22840773%20AND%20SRC:MED&resulttype=core&format=json