Complexin cross-links prefusion SNAREs into a zigzag array (Q27670976)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785414%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Complexin cross-links prefusion SNAREs into a zigzag array (English)

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8 February 2020

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Shyam S. Krishnakumar

2

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8 February 2020

Frédéric Pincet

6

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8 February 2020

7

James E Rothman

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8 February 2020

author name string

Daniel Kümmel

1

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8 February 2020

Daniel T Radoff

3

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8 February 2020

Feng Li

4

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8 February 2020

Claudio G Giraudo

5

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8 February 2020

Karin M Reinisch

8

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8 February 2020

language of work or name

English

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publication date

24 July 2011

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Nature Structural & Molecular Biology

8 February 2020

published in

1 reference

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8 February 2020

volume

18

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8 February 2020

issue

8

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8 February 2020

page(s)

927-933

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Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix

8 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Helical extension of the neuronal SNARE complex into the membrane

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Complexin controls the force transfer from SNARE complexes to membranes in fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Membrane fusion: grappling with SNARE and SM proteins

20 March 2017

1 reference

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Spontaneous subthreshold activity at motor nerve endings

20 March 2017

1 reference

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X-ray structure of a neuronal complexin-SNARE complex from squid

20 March 2017

1 reference

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Three-dimensional structure of the complexin/SNARE complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Complexins: cytosolic proteins that regulate SNAP receptor function

20 March 2017

1 reference

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Phasercrystallographic software

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

2 references

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20 March 2017

https://api.crossref.org/works/10.1038/NSMB.2101

Preparation of selenomethionyl proteins for phase determination

22 April 2017

1 reference

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Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

SNAP receptors implicated in vesicle targeting and fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

SNAREpins: minimal machinery for membrane fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Synaptotagmin I functions as a calcium regulator of release probability

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Complexin has opposite effects on two modes of synaptic vesicle fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Complexin maintains vesicles in the primed state in C. elegans

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Alternative zippering as an on-off switch for SNARE-mediated fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

A fast, single-vesicle fusion assay mimics physiological SNARE requirements

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

29 September 2017

1 reference

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Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Membranes of the world unite!

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

A clamping mechanism involved in SNARE-dependent exocytosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

SNARE-driven, 25-millisecond vesicle fusion in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Fusion of cells by flipped SNAREs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

A quantitative model for membrane fusion based on low-energy intermediates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Complexins regulate a late step in Ca2+-dependent neurotransmitter release

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Where freedom is given, liberties are taken

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410656

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

2 June 2018

1 reference

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

21 January 2018

1 reference

Distinct domains of complexin I differentially regulate neurotransmitter release

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Activity-dependent changes in partial VAMP complexes during neurotransmitter release

21 January 2018

1 reference

Principles of Fluorescence Spectroscopy

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2101

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785414%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 February 2020

1008502465

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785414%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

2 references