Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor (Q27671875)

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12 February 2020

title

Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor (English)

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12 February 2020

6

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author name string

Nachum Kaplan

1

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12 February 2020

Monique Albert

2

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Donald Awrey

3

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12 February 2020

Elias Bardouniotis

4

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Judd Berman

5

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12 February 2020

Mandy Dorsey

7

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Barry Hafkin

8

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Jaillal Ramnauth

9

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12 February 2020

Vladimir Romanov

10

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12 February 2020

Molly B Schmid

11

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12 February 2020

Rosanne Thalakada

12

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Jeremy Yethon

13

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Henry W Pauls

14

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12 February 2020

language of work or name

English

0 references

publication date

4 September 2012

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Antimicrobial Agents and Chemotherapy

12 February 2020

published in

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12 February 2020

volume

56

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12 February 2020

issue

11

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12 February 2020

page(s)

5865-5874

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Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality

12 February 2020

cites work

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Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

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Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data

20 March 2017

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20 March 2017

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Vibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductase

20 March 2017

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The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis

20 March 2017

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20 March 2017

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

7 April 2017

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Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.

7 April 2017

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Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study

29 September 2017

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29 September 2017

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The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus

29 September 2017

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Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway

29 September 2017

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Determination of selectivity and efficacy of fatty acid synthesis inhibitors

29 September 2017

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Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus

29 September 2017

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Discovery of a novel and potent class of FabI-directed antibacterial agents

29 September 2017

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AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity

29 September 2017

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2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus

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27 November 2018

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27 November 2018

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22948878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22948878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Community-acquired methicillin-resistant Staphylococcus aureus infections: a new source for nosocomial outbreaks

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22948878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.01411-12

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22948878%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

2 references

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12 February 2020

2 references

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