Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia (Q27674083)

1

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Qingxiang Sun

2

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Katie Williams

3

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Larissa Tangeman

4

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Shruti Jha

5

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Yiming Zhong

6

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Virginia Goettl

7

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Emilia Mahoney

8

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Caroline Berglund

9

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Sneha Gupta

10

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Alicia Farmer

11

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Rajeswaran Mani

12

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Amy J Johnson

13

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David Lucas

14

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Xiaokui Mo

15

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Dirk Daelemans

16

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Vincent Sandanayaka

17

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Sharon Shechter

18

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Dilara McCauley

19

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Sharon Shacham

20

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Michael Kauffman

21

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Yuh Min Chook

Nuclear export of proteins and drug resistance in cancer

22

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language of work or name

English

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publication date

29 November 2012

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published in

Blood

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volume

120

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issue

23

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page(s)

4621-34

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cites work

1 reference

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NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

20 March 2017

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An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

20 March 2017

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Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP

20 March 2017

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Structural basis for leucine-rich nuclear export signal recognition by CRM1

20 March 2017

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Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

20 March 2017

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CRM1-mediated recycling of snurportin 1 to the cytoplasm

20 March 2017

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20 March 2017

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The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo

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20 March 2017

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

20 March 2017

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7 April 2017

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CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

29 September 2017

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29 September 2017

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The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia

29 September 2017

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Understanding and managing ultra high-risk chronic lymphocytic leukemia

29 September 2017

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Recognition of nuclear targeting signals by Karyopherin-β proteins

29 September 2017

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Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway

29 September 2017

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From pathogenesis to treatment of chronic lymphocytic leukaemia

29 September 2017

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Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

29 September 2017

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Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition

29 September 2017

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Identification of nuclear export inhibitors with potent anticancer activity in vivo

29 September 2017

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CRM1-mediated nuclear export of proteins and drug resistance in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Reorganization of the nuclear envelope during open mitosis

29 September 2017

1 reference

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Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

29 September 2017

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Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

29 September 2017

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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

29 September 2017

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Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

29 September 2017

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Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia

29 September 2017

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Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

29 September 2017

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Apoptosis-based therapies for hematologic malignancies

29 September 2017

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Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo

29 September 2017

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Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

29 September 2017

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Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Nuclear transport and cancer: from mechanism to intervention

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Phase I trial of elactocin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

The expression of CRM1 is associated with prognosis in human osteosarcoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721).

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3512237

Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23034282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2012-05-429506

1 reference

release_6mr7zlwgbbdmnfthkxz7cmwjzm

2187537

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6mr7zlwgbbdmnfthkxz7cmwjzm

mapped directly with Wikidata item

24 November 2022

based on heuristic

2187537

1 reference

1 reference

1 reference