Interaction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli (Q27674591)

2

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Tonya N Zeczycki

3

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Sudhanshu Kumar

4

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Paul V Attwood

5

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John C Wallace

6

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W Wallace Cleland

7

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Martin St Maurice

Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase

8

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language of work or name

English

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publication date

15 November 2011

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published in

Biochemistry

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volume

50

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issue

45

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page(s)

9708-23

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cites work

1 reference

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A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A

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Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism

20 March 2017

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Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase

20 March 2017

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Structure, mechanism and regulation of pyruvate carboxylase

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Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

20 March 2017

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Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme

20 March 2017

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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

20 March 2017

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Movement of the biotin carboxylase B-domain as a result of ATP binding

20 March 2017

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A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

20 March 2017

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Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase

20 March 2017

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Phasercrystallographic software

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

20 March 2017

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20 March 2017

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

29 September 2017

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Activation and inhibition of pyruvate carboxylase from Rhizobium etli

7 April 2017

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Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli

29 September 2017

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Probing the allosteric activation of pyruvate carboxylase using 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA.

29 September 2017

1 reference

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Quaternary structure of the oxaloacetate decarboxylase membrane complex and mechanistic relationships to pyruvate carboxylases.

29 September 2017

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Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase.

29 September 2017

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Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis

29 September 2017

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Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice

29 September 2017

1 reference

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Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)

29 September 2017

1 reference

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Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

29 September 2017

1 reference

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Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase

29 September 2017

1 reference

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Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA.

29 September 2017

1 reference

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Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis

29 September 2017

1 reference

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Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion

29 September 2017

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Anaplerotic roles of pyruvate carboxylase in mammalian tissues

29 September 2017

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Protein engineering of pyruvate carboxylase: investigation on the function of acetyl-CoA and the quaternary structure.

29 September 2017

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Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin

29 September 2017

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Further electron microscope studies on pyruvate carboxylase

29 September 2017

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Induction of pyruvate carboxylase apoenzyme and holoenzyme in 3T3-L1 cells during differentiation

29 September 2017

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The mechanism of biotin-dependent enzymes

29 September 2017

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Insight into the carboxyl transferase domain mechanism of pyruvate carboxylase from Rhizobium etli.

29 September 2017

1 reference

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Function of Escherichia coli biotin carboxylase requires catalytic activity of both subunits of the homodimer

2 June 2018

1 reference

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Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes.

2 June 2018

1 reference

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The existence of multiple tetrameric conformers of chicken liver pyruvate carboxylase and their roles in dilution inactivation

2 June 2018

1 reference

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Factors that influence the translocation of the N-carboxybiotin moiety between the two sub-sites of pyruvate carboxylase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3214759

Rat liver pyruvate carboxylase. 3. Isotopic exchange studies of the first partial reaction

2 June 2018

1 reference

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The carboxybiotin complex of chicken liver pyruvate carboxylase. A kinetic analysis of the effects of acetyl-CoA, Mg2+ ions and temperature on its stability and on its reaction with 2-oxobutyrate

2 June 2018

1 reference

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Pyruvate carboxylase catalysis of phosphate transfer between carbamoyl phosphate and ADP.

2 June 2018

1 reference

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Bicarbonate-dependent ATP cleavage catalysed by pyruvate carboxylase in the absence of pyruvate

2 June 2018

1 reference

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Sheep kidney pyruvate carboxylase. Studies on the coupling of adenosine triphosphate hydrolysis and CO2 fixation

2 June 2018

1 reference

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Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency.

2 June 2018

1 reference

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Insights into the mechanism and regulation of pyruvate carboxylase by characterisation of a biotin-deficient mutant of the Bacillus thermodenitrificans enzyme.

27 November 2018

1 reference

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Modeling and numerical simulation of biotin carboxylase kinetics: implications for half-sites reactivity.

27 November 2018

1 reference

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Escherichia coli acetyl-coenzyme A carboxylase: characterization and development of a high-throughput assay

27 November 2018

1 reference

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Construction of new forms of pyruvate carboxylase to assess the allosteric regulation by acetyl-CoA.

27 November 2018

1 reference

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Changes in catalytic activity and association state of pyruvate carboxylase which are dependent on enzyme concentration.

27 November 2018

1 reference

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Kinetic characterization of yeast pyruvate carboxylase isozyme pyc1.

27 November 2018

1 reference

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The biotin domain peptide from the biotin carboxyl carrier protein of Escherichia coli acetyl-CoA carboxylase causes a marked increase in the catalytic efficiency of biotin carboxylase and carboxyltransferase relative to free biotin

27 November 2018

1 reference

12 December 2020

Inhibition of biotin carboxylase by a reaction intermediate analog: implications for the kinetic mechanism

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12 December 2020

Conserved Glu40 and Glu433 of the biotin carboxylase domain of yeast pyruvate carboxylase I isoenzyme are essential for the association of tetramers

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12 December 2020

13C NMR study of hepatic pyruvate carboxylase activity in tumor rats

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Pyruvate carboxylase from Aspergillus nidulans. Effects of regulatory modifiers on the structure of the enzyme

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12 December 2020

Effect of carbonic anhydrase inhibition and acetoacetate on anaplerotic pyruvate carboxylase activity in cultured rat astrocytes

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12 December 2020