Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. (Q27675570)

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English	Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.	scientific article

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21 February 2020

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding (English)

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21 February 2020

structural biology

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Benjamin I Leach

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21 February 2020

John H Bushweller

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21 February 2020

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Aravinda Kuntimaddi

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21 February 2020

Charles R Schmidt

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21 February 2020

Tomasz Cierpicki

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21 February 2020

Stephanie A Johnson

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21 February 2020

publication date

20 December 2012

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21 February 2020

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21 February 2020

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21 February 2020

1

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21 February 2020

176-183

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21 February 2020

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

1 reference

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Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

1 reference

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

1 reference

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DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

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The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias

1 reference

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HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties

1 reference

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The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor

1 reference

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IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

1 reference

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1 reference

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Coupling of local folding to site-specific binding of proteins to DNA

1 reference

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Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1 reference

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Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

1 reference

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1 reference

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Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

1 reference

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

1 reference

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The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545106

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545106

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Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner

1 reference

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The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545106

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MLL fusion partners AF4 and AF9 interact at subnuclear foci

1 reference

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Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

1 reference

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1 reference

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New insights to the MLL recombinome of acute leukemias

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Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23260655

12 December 2020

based on heuristic

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Identifiers

10.1016/J.STR.2012.11.011

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21 February 2020

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21 February 2020

1 reference

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21 February 2020

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