Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange (Q27675571)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22084083%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange (English)

1 reference

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16 January 2020

4

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16 January 2020

author name string

Corrie A Painter

1

1 reference

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16 January 2020

Maria P Negroni

2

1 reference

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16 January 2020

Katherine A Kellersberger

3

1 reference

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16 January 2020

James E Evans

5

1 reference

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16 January 2020

Lawrence J Stern

6

1 reference

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16 January 2020

language of work or name

English

0 references

publication date

14 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22084083%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

16 January 2020

published in

1 reference

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16 January 2020

volume

108

1 reference

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16 January 2020

issue

48

1 reference

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16 January 2020

page(s)

19329-19334

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22084083%20AND%20SRC:MED&resulttype=core&format=json

PHENIX: a comprehensive Python-based system for macromolecular structure solution

16 January 2020

cites work

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20 March 2017

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An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

20 March 2017

1 reference

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HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

20 March 2017

1 reference

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Phasercrystallographic software

20 March 2017

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20 March 2017

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Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides

20 March 2017

1 reference

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HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH

20 March 2017

1 reference

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Editing of the HLA-DR-peptide repertoire by HLA-DM

20 March 2017

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Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

20 March 2017

1 reference

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Characterization of structural features controlling the receptiveness of empty class II MHC molecules.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Model for the peptide-free conformation of class II MHC proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Hydrogen/deuterium exchange-mass spectrometry: a powerful tool for probing protein structure, dynamics and interactions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Stabilization of soluble, low-affinity HLA-DM/HLA-DR1 complexes by leucine zippers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

The kinetic basis of peptide exchange catalysis by HLA-DM

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Determination of the HLA-DM interaction site on HLA-DR molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules

29 September 2017

1 reference

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Role for intracellular proteases in the processing and transport of class II HLA antigens

29 September 2017

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Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.

29 September 2017

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Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM.

2 June 2018

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Mediation by HLA-DM of dissociation of peptides from HLA-DR

2 June 2018

1 reference

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Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108074108

Structural factors contributing to DM susceptibility of MHC class II/peptide complexes

21 January 2018

1 reference

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DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis

21 January 2018

1 reference

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Identification of the HLA-DM/HLA-DR interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108074108

Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108074108

Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1108074108

Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228433

A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22084083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22084083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1108074108

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22084083%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

ADS bibcode

2011PNAS..10819329P

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22084083%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

22084083

2 references