A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides (Q27675767)

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English	A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides	scientific article

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scholarly article

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A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides (English)

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antibiotic resistance

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author name string

Jiro Kondo

1

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language of work or name

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publication date

9 January 2012

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Angewandte Chemie International Edition

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51

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2

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465-8

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Aminoglycoside antibiotics: old drugs and new therapeutic approaches

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

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Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

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Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site

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Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide

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Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site

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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

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Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group

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Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity

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Monitoring molecular recognition of the ribosomal decoding site

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Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex

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Molecular recognition of RNA by neomycin and a restricted neomycin derivative.

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A model for the study of ligand binding to the ribosomal RNA helix h44

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A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae

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Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon

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Discordant resistance to kanamycin and amikacin in drug-resistant Mycobacterium tuberculosis

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Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis

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Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.

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High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene

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Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic.

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Molecular mechanism of gentamicin resistance in Bartonella henselae

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Basis for prokaryotic specificity of action of aminoglycoside antibiotics

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The Molecular Basis for A‐Site Mutations Conferring Aminoglycoside Resistance: Relationship between Ribosomal Susceptibility and X‐ray Crystal Structures

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Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus

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Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction

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Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.

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A genetic model to investigate drug-target interactions at the ribosomal decoding site

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Biological activity of antibiotic G-418, a new micromonospora-produced aminoglycoside with activity against protozoa and helminths

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Antibiotic G-418, a New Micromonospora-Produced Aminoglycoside with Activity Against Protozoa and Helminths: Antiparasitic Activity

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Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria

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Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1

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Structural basis for mRNA and tRNA positioning on the ribosome

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Fitness cost of chromosomal drug resistance-conferring mutations

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10.1002/ANIE.201106084

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