Binary complex crystal structure of DNA polymerase reveals multiple conformations of the templating 8-oxoguanine lesion (Q27676274)

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18 January 2020

title

Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion (English)

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18 January 2020

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5

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18 January 2020

author name string

Vinod K Batra

1

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18 January 2020

David D Shock

2

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18 January 2020

William A Beard

3

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18 January 2020

Charles E McKenna

4

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18 January 2020

language of work or name

English

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publication date

16 December 2011

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Proceedings of the National Academy of Sciences of the United States of America

18 January 2020

published in

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18 January 2020

volume

109

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18 January 2020

issue

1

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18 January 2020

page(s)

113-118

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Mutagenic conformation of 8-oxo-7,8-dihydro-2′-dGTP in the confines of a DNA polymerase active site

18 January 2020

cites work

1 reference

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Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP To Be Inserted opposite 7,8-Dihydro-8-oxoguanine,

20 March 2017

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Kinetics of Mismatch Formation opposite Lesions by the Replicative DNA Polymerase from Bacteriophage RB69

20 March 2017

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A comprehensive catalogue of somatic mutations from a human cancer genome

20 March 2017

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Structural and Functional Elucidation of the Mechanism Promoting Error-prone Synthesis by Human DNA Polymerase Opposite the 7,8-Dihydro-8-oxo-2'-deoxyguanosine Adduct

20 March 2017

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Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion

20 March 2017

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Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases

20 March 2017

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Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

20 March 2017

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Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing

20 March 2017

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Lesion (in)tolerance reveals insights into DNA replication fidelity

20 March 2017

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Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential

20 March 2017

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

20 March 2017

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The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

20 March 2017

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8-Hydroxyguanine: From its discovery in 1983 to the present status

7 April 2017

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DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine.

29 September 2017

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Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase

29 September 2017

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient

29 September 2017

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DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

29 September 2017

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Lesion processing: high-fidelity versus lesion-bypass DNA polymerases

29 September 2017

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Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

29 September 2017

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Structure and mechanism of DNA polymerase Beta.

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Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase

29 September 2017

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Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.

29 September 2017

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Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases

29 September 2017

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29 September 2017

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Repair of 8-oxoguanine and Ogg1-incised apurinic sites in a CHO cell line

29 September 2017

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Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage

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Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA.

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Comparison of the mutagenic properties of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA lesions in mammalian cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Chemical determination of free radical-induced damage to DNA

29 September 2017

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A highly conserved Tyrosine residue of family B DNA polymerases contributes to dictate translesion synthesis past 8-oxo-7,8-dihydro-2'-deoxyguanosine

29 September 2017

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Purification and domain-mapping of mammalian DNA polymerase beta.

2 June 2018

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Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors

2 June 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1112235108

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1112235108

Dynamic behavior of DNA base pairs containing 8-oxoguanine

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1112235108

Carbon-13 magnetic resonance spectra of 8-substituted purine nucleosides. Characteristic shifts for the syn conformation

21 January 2018

1 reference

12 December 2020

Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-

1 reference

12 December 2020

Structural and conformational analyses of 8-hydroxy-2'-deoxyguanosine

1 reference

12 December 2020

Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1112235108

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22178760%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

ADS bibcode

2012PNAS..109..113B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22178760%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

22178760

2 references