Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase (Q27676660)

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24 February 2020

title

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase (English)

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24 February 2020

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3

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24 February 2020

author name string

He Huang

1

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24 February 2020

Huiying Li

2

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24 February 2020

Linda J Roman

4

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24 February 2020

Thomas L Poulos

5

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24 February 2020

Richard B Silverman

6

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24 February 2020

language of work or name

English

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publication date

28 March 2013

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Journal of Medicinal Chemistry

24 February 2020

published in

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24 February 2020

volume

56

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24 February 2020

issue

7

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24 February 2020

page(s)

3024-3032

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Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations

24 February 2020

cites work

1 reference

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Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

20 March 2017

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Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase

20 March 2017

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The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

20 March 2017

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

20 March 2017

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20 March 2017

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Nitric oxide synthases: structure, function and inhibition

29 September 2017

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Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease

20 March 2017

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Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase

20 March 2017

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29 September 2017

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Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases

29 September 2017

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Discovering novel 3-nitroquinolines as a new class of anticancer agents

29 September 2017

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Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols

29 September 2017

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Subcellular targeting and trafficking of nitric oxide synthases

29 September 2017

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Blocking NO synthesis: how, where and why?

29 September 2017

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Mechanism of free-radical generation by nitric oxide synthase

29 September 2017

1 reference

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Characterization of bovine endothelial nitric oxide synthase expressed in E. coli.

29 September 2017

1 reference

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High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli

29 September 2017

1 reference

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Discovery and development of neuronal nitric oxide synthase inhibitors

29 September 2017

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12 December 2020

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein

1 reference

12 December 2020

Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities

1 reference

12 December 2020

1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

[25] Nitric-oxide synthase assays

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12 December 2020

Identifiers

DOI

10.1021/JM4000984

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23451760%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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24 February 2020

PubMed publication ID

23451760

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23451760%20AND%20SRC:MED&resulttype=core&format=json