The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508 (Q27676963)

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21 January 2020

title

The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508 (English)

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21 January 2020

3

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4

Jane A Endicott

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21 January 2020

author name string

Sonja Baumli

series ordinal

1

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21 January 2020

Alison J Hole

series ordinal

2

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21 January 2020

publication date

10 February 2012

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21 January 2020

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21 January 2020

volume

7

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21 January 2020

issue

5

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21 January 2020

page(s)

811-816

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CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

21 January 2020

cites work

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The conformational plasticity of protein kinases

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CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

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Cyclin-dependent kinase inhibitor, P276-00 induces apoptosis in multiple myeloma cells by inhibition of Cdk9-T1 and RNA polymerase II-dependent transcription

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Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

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4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

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29 September 2017

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The selective P-TEFb inhibitor CAN508 targets angiogenesis.

29 September 2017

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27 November 2018

Identifiers

DOI

10.1021/CB2004516

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21 January 2020

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21 January 2020

PubMed publication ID

22292676

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