The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold (Q27677595)

8

0 references

Zachary A Bornholdt

Zachary A Bornholdt

2

0 references

Dafna M. Abelson

4

Dafna M Abelson

0 references

Adrianna P. P. Zhang

1

Adrianna P P Zhang

0 references

Virgil L. Woods

7

Virgil L Woods

0 references

author name string

Tong Liu

3

0 references

David E Lee

5

0 references

Sheng Li

Creative Commons Attribution 4.0 International

6

0 references

language of work or name

English

0 references

publication date

February 2012

0 references

published in

PLOS Pathogens

0 references

volume

8

0 references

page(s)

e1002550

0 references

issue

2

0 references

copyright license

start time

23 February 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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29 September 2017

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20 March 2017

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Mechanisms of type-I- and type-II-interferon-mediated signalling

20 March 2017

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Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

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20 March 2017

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Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

20 March 2017

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Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

20 March 2017

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20 March 2017

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Auto-rickshaw: an automated crystal structure determination platform as an efficient tool for the validation of an X-ray diffraction experiment

7 April 2017

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

7 April 2017

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7 April 2017

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7 April 2017

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29 September 2017

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Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells

29 September 2017

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Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcription

29 September 2017

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STAT1 and pathogens, not a friendly relationship

29 September 2017

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29 September 2017

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29 September 2017

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Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

29 September 2017

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29 September 2017

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Human metapneumovirus inhibits IFN-alpha signaling through inhibition of STAT1 phosphorylation.

29 September 2017

1 reference

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Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome

29 September 2017

1 reference

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Regions in Ebola virus VP24 that are important for nucleocapsid formation

29 September 2017

1 reference

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Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

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29 September 2017

1 reference

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Molecular determinants of Ebola virus virulence in mice

29 September 2017

1 reference

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Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence

29 September 2017

1 reference

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Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways

29 September 2017

1 reference

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VP24 of Marburg virus influences formation of infectious particles

29 September 2017

1 reference

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Nucleocytoplasmic shuttling of STAT transcription factors.

29 September 2017

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29 September 2017

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Pathogenesis of filoviral haemorrhagic fevers

29 September 2017

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Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation

29 September 2017

1 reference

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Of JAKs, STATs, blind watchmakers, jeeps and trains

29 September 2017

1 reference

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Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

29 September 2017

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Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3.

29 September 2017

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So many ligands, so few transcription factors: a new paradigm for signaling through the STAT transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Molecular characterization of guinea pig-adapted variants of Ebola virus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

29 September 2017

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Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients

29 September 2017

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Regulation of STAT-dependent pathways by growth factors and cytokines.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Human natural interferon-alpha producing cells

29 September 2017

1 reference

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Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells

29 September 2017

1 reference

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On the combination of molecular replacement and single-wavelength anomalous diffraction phasing for automated structure determination

29 September 2017

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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

2 June 2018

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PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry

2 June 2018

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Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway

2 June 2018

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Mapping of the cytoplasmic domain of the human growth hormone receptor required for the activation of Jak2 and Stat proteins

2 June 2018

1 reference

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Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients

2 June 2018

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Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation.

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk.

21 January 2018

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A solution for the best rotation to relate two sets of vectors

21 January 2018

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Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285596

Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22383882

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1002550

1 reference

3095017

3095017

1 reference

1 reference

1 reference