"Snapshots"of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5 (Q27678058)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23658017%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5 (English)

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1 March 2020

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4

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1 March 2020

author name string

Hung Yi Kristal Kaan

1

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1 March 2020

Jennifer Major

2

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1 March 2020

Katarzyna Tkocz

3

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1 March 2020

Steven S Rosenfeld

5

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1 March 2020

language of work or name

English

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publication date

8 May 2013

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Journal of Biological Chemistry

1 March 2020

published in

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1 March 2020

volume

288

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1 March 2020

issue

25

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1 March 2020

page(s)

18588-18598

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The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

1 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

The structure of the ternary Eg5–ADP–ispinesib complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Loop L5 acts as a conformational latch in the mitotic kinesin Eg5

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Monastrol inhibition of the mitotic kinesin Eg5.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Overview of the CCP4 suite and current developments

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

PHENIX: building new software for automated crystallographic structure determination

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

20 March 2017

https://api.crossref.org/works/10.1074%2FJBC.M113.462648

Remarks about protein structure precision

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Crystal structure of the motor domain of the human kinetochore protein CENP-E

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Structural kinetics of myosin by transient time-resolved FRET

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Southwest Oncology Group phase II study of ispinesib in androgen-independent prostate cancer previously treated with taxanes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Allosteric inhibition of kinesin-5 modulates its processive directional motility.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

A structural model for monastrol inhibition of dimeric kinesin Eg5.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

Equilibrium studies of kinesin-nucleotide intermediates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3689998

A pathway of structural changes produced by monastrol binding to Eg5.

29 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.462648

Mechanism of inhibition of human KSP by ispinesib

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.462648

Docking and rolling, a model of how the mitotic motor Eg5 works

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.462648

ATP reorients the neck linker of kinesin in two sequential steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.462648

Transient kinetics of adenosine 5'-diphosphate and adenosine 5'-(beta, gamma-imidotriphosphate) binding to subfragment 1 and actosubfragment 1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23658017

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23658017

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.462648

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23658017%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23658017%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

23658017

1 reference