Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K + channel (Q27678292)

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1 March 2020

title

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel (English)

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1 March 2020

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1

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1 March 2020

Anirban Banerjee

2

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1 March 2020

author name string

Alice Lee

3

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1 March 2020

Ernest Campbell

4

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1 March 2020

Roderick Mackinnon

5

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1 March 2020

language of work or name

English

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publication date

21 May 2013

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1 March 2020

2 references

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1 March 2020

volume

2

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1 March 2020

page(s)

e00594

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

1 March 2020

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Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

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The Occupancy of Ions in the K+ Selectivity Filter: Charge Balance and Coupling of Ion Binding to a Protein Conformational Change Underlie High Conduction Rates

20 March 2017

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X-ray structure of a voltage-dependent K+ channel

20 March 2017

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Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

20 March 2017

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Energetic optimization of ion conduction rate by the K+ selectivity filter

20 March 2017

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

20 March 2017

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Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins

20 March 2017

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Kaliotoxin (1-37) shows structural differences with related potassium channel blockers

20 March 2017

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20 March 2017

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20 March 2017

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

22 April 2017

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Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry

20 March 2017

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Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

20 March 2017

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Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

20 March 2017

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Refined Structure of Charybdotoxin: Common Motifs in Scorpion Toxins and Insect Defensins

20 March 2017

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Determination of the subunit stoichiometry of a voltage-activated potassium channel

20 March 2017

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Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus

20 March 2017

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Mining on scorpion venom biodiversity

20 March 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Animal peptides targeting voltage-activated sodium channels.

29 September 2017

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Conus venoms - a rich source of peptide-based therapeutics

29 September 2017

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Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR.

29 September 2017

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Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.

29 September 2017

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Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

29 September 2017

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29 September 2017

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A symmetry-driven search for electrostatic interaction partners in charybdotoxin and a voltage-gated K+ channel

29 September 2017

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A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel.

29 September 2017

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An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula

29 September 2017

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The charybdotoxin family of K+ channel-blocking peptides

29 September 2017

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Electrostatic distance geometry in a K+ channel vestibule

29 September 2017

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Mechanism of charybdotoxin block of a voltage-gated K+ channel.

29 September 2017

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Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin.

29 September 2017

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Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel

29 September 2017

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Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength

29 September 2017

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Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila

29 September 2017

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Design, synthesis, and functional expression of a gene for charybdotoxin, a peptide blocker of K+ channels

29 September 2017

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Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel.

29 September 2017

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A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.

29 September 2017

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Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins.

29 September 2017

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Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers

2 June 2018

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2 June 2018

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Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.

2 June 2018

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The signature sequence of voltage-gated potassium channels projects into the external vestibule

2 June 2018

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2 June 2018

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Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor

2 June 2018

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Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

2 June 2018

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Mapping hydrophobic residues of the interaction surface of charybdotoxin

2 June 2018

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Transfer of the scorpion toxin receptor to an insensitive potassium channel.

2 June 2018

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Agitoxin footprinting the shaker potassium channel pore.

21 January 2018

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Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

21 January 2018

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Collaborative Computational Project, number 4: providing programs for protein crystallography.

21 January 2018

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Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle

27 November 2018

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Determination of the three-dimensional structure of iberiotoxin in solution by 1H nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23705070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural basis of the KcsA K(+) channel and agitoxin2 pore-blocking toxin interaction by using the transferred cross-saturation method

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23705070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intimations of K+ channel structure from a complete functional map of the molecular surface of charybdotoxin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23705070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.00594

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705070%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23705070%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2 references