Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA (Q27678475)

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28 January 2020

title

Structure of hepatitis C virus polymerase in complex with primer-template RNA (English)

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28 January 2020

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28 January 2020

author name string

Ralph T Mosley

1

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28 January 2020

Eisuke Murakami

3

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Angela M Lam

4

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28 January 2020

Rena L Grice

5

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28 January 2020

Jinfa Du

6

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28 January 2020

Michael J Sofia

7

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28 January 2020

Philip A Furman

8

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28 January 2020

Michael J Otto

9

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publication date

11 April 2012

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28 January 2020

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28 January 2020

volume

86

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28 January 2020

issue

12

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28 January 2020

page(s)

6503-6511

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A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

28 January 2020

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20 March 2017

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Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin

20 March 2017

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Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

20 March 2017

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Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

20 March 2017

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Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

20 March 2017

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Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5

20 March 2017

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Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

20 March 2017

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General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

20 March 2017

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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

20 March 2017

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Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation

20 March 2017

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

20 March 2017

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A mechanism for initiating RNA-dependent RNA polymerization

20 March 2017

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De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

20 March 2017

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20 March 2017

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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

20 March 2017

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

20 March 2017

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase

7 April 2017

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An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors

29 September 2017

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29 September 2017

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Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.

27 November 2018

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Structural biology of hepatitis C virus

27 November 2018

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HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA.

27 November 2018

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Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin

27 November 2018

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A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

27 November 2018

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27 November 2018

Identifiers

DOI

10.1128/JVI.00386-12

2 references

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28 January 2020

1 reference

2 references

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28 January 2020

PubMed publication ID

22496223

2 references