Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a) (Q27678595)

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English	Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)	scientific article

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3 March 2020

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a) (English)

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3 March 2020

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3 March 2020

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Natali A Minassian

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3 March 2020

Amy Y Shih

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3 March 2020

Yi Liu

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3 March 2020

Robert A Neff

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3 March 2020

Steven W Sutton

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3 March 2020

Tara Mirzadegan

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3 March 2020

Judith Connor

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3 March 2020

Ross Fellows

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3 March 2020

Matthew Husovsky

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3 March 2020

Serena Nelson

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3 March 2020

Michael J Hunter

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3 March 2020

Mack Flinspach

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3 March 2020

Alan D Wickenden

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3 March 2020

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12 June 2013

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3 March 2020

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Journal of Biological Chemistry

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3 March 2020

288

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3 March 2020

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3 March 2020

22707-22720

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3 March 2020

The crystal structure of a voltage-gated sodium channel

1 reference

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ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

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20 March 2017

Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels

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Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus

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Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

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20 March 2017

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

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20 March 2017

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins

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Automated NMR structure calculation with CYANA

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SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

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An SCN9A channelopathy causes congenital inability to experience pain

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Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

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Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels

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29 September 2017

Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels

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29 September 2017

Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2.

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29 September 2017

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV

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29 September 2017

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

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29 September 2017

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel

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Prediction of protein-protein interaction sites using electrostatic desolvation profiles

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29 September 2017

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

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29 September 2017

A stop codon mutation in SCN9A causes lack of pain sensation

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29 September 2017

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29 September 2017

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Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV

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21 January 2018

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

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