Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism (Q27679007)

7

0 references

Giang Thi Tuyet Nguyen

3

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Melanie Gertz

1

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Michael Weyand

6

0 references

Mike Schutkowski

object named as

Mike Schutkowski

5

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author name string

Frank Fischer

2

0 references

Mahadevan Lakshminarasimhan

Proceedings of the National Academy of Sciences of the United States of America

4

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language of work or name

English

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publication date

23 July 2013

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published in

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volume

110

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page(s)

E2772-81

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issue

30

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cites work

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Sirt1 activation by resveratrol is substrate sequence-selective

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

29 September 2017

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Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

29 September 2017

1 reference

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Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

Structural basis for the mechanism and regulation of Sir2 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

One-step, nonenzymatic synthesis of O-acetyl-ADP-ribose and analogues from NAD and carboxylates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

The Structural Basis of Sirtuin Substrate Affinity†,‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1303628110

21 January 2018

Identifiers

DOI

10.1073/PNAS.1303628110

1 reference

1200780

ADS bibcode

2013PNAS..110E2772G

0 references

1200780

1 reference

1 reference

1 reference