Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation (Q27679366)

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2 February 2020

title

Crystal structures of Trypanosoma cruzi UDP-galactopyranose mutase implicate flexibility of the histidine loop in enzyme activation (English)

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2 February 2020

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5

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2 February 2020

author name string

Richa Dhatwalia

1

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2 February 2020

Harkewal Singh

2

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2 February 2020

Michelle Oppenheimer

3

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2 February 2020

Pablo Sobrado

4

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2 February 2020

language of work or name

English

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publication date

5 June 2012

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2 February 2020

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2 February 2020

volume

51

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2 February 2020

issue

24

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2 February 2020

page(s)

4968-4979

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Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus

2 February 2020

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Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus

20 March 2017

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Chemoenzymatic synthesis, inhibition studies, and X-ray crystallographic analysis of the phosphono analog of UDP-Galp as an inhibitor and mechanistic probe for UDP-galactopyranose mutase

20 March 2017

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20 March 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

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Structural basis of substrate binding to UDP-galactopyranose mutase: crystal structures in the reduced and oxidized state complexed with UDP-galactopyranose and UDP

20 March 2017

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X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin

20 March 2017

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Ligand Binding and Substrate Discrimination by UDP-Galactopyranose Mutase

20 March 2017

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UDP-galactopyranose mutase has a novel structure and mechanism

20 March 2017

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20 March 2017

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Inference of macromolecular assemblies from crystalline state

20 March 2017

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Scaling and assessment of data quality

20 March 2017

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20 March 2017

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20 March 2017

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Structure validation by Calpha geometry: phi,psi and Cbeta deviation

20 March 2017

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Solvent content of protein crystals

20 March 2017

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Chemical mechanism of UDP-galactopyranose mutase from Trypanosoma cruzi: a potential drug target against Chagas' disease

20 March 2017

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Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase

20 March 2017

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Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact.

29 September 2017

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Chagas disease has now gone global

29 September 2017

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Protonation, tautomerization, and rotameric structure of histidine: a comprehensive study by magic-angle-spinning solid-state NMR.

29 September 2017

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Flavin redox switching of protein functions

29 September 2017

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Evaluation and treatment of chagas disease in the United States: a systematic review

29 September 2017

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Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major

29 September 2017

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Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens

29 September 2017

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The LPG1 gene family of Leishmania major

29 September 2017

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A unique catalytic mechanism for UDP-galactopyranose mutase

29 September 2017

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29 September 2017

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29 September 2017

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GPI-anchored glycoconjugates from Trypanosoma cruzi trypomastigotes are recognized by lytic anti-alpha-galactosyl antibodies isolated from patients with chronic Chagas' disease.

29 September 2017

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29 September 2017

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Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state

2 June 2018

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2 June 2018

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27 November 2018

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Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus

27 November 2018

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An Estimate of the Burden of Chagas Disease in the United States

27 November 2018

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The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

27 November 2018

1 reference

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The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

27 November 2018

1 reference

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Chagas' disease: lymphoma growth in rabbits treated with Benznidazole

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3426654

Trypanosoma cruzi uses a 45-kDa mucin for adhesion to mammalian cells

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22646091

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12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22646091

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI300498C

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2 February 2020

Fatcat ID

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Fatcat

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24 November 2022

based on heuristic

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2 February 2020

PubMed publication ID

22646091

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