Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex (Q27679392)

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2 February 2020

title

Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex (English)

1 reference

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Circadian locomotor output cycles kaput

2 February 2020

main subject

crystal structure

0 references

1 reference

Aryl hydrocarbon receptor nuclear translocator-like

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Joseph Takahashi

9

1 reference

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2 February 2020

author name string

Nian Huang

1

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2 February 2020

Yogarany Chelliah

2

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2 February 2020

Yongli Shan

3

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2 February 2020

Clinton A Taylor

4

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2 February 2020

Seung-Hee Yoo

5

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2 February 2020

Carrie Partch

6

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2 February 2020

Carla B Green

7

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2 February 2020

Hong Zhang

8

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2 February 2020

language of work or name

English

0 references

publication date

31 May 2012

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2 February 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

Science

1 reference

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2 February 2020

volume

337

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2 February 2020

issue

6091

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2 February 2020

page(s)

189-194

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Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

2 February 2020

cites work

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SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

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Crystal structure of the N-terminal domain of the TyrR transcription factor responsible for gene regulation of aromatic amino acid biosynthesis and transport in Escherichia coli K12

20 March 2017

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Feedback repression is required for mammalian circadian clock function

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SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

20 March 2017

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A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

20 March 2017

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PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

20 March 2017

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20 March 2017

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Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain

20 March 2017

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20 March 2017

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Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation

20 March 2017

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CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

20 March 2017

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20 March 2017

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20 March 2017

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Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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7 April 2017

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mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

7 April 2017

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How eukaryotic transcriptional activators work

7 April 2017

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7 April 2017

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Ligand-binding PAS domains in a genomic, cellular, and structural context

29 September 2017

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Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B

29 September 2017

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Temperature as a universal resetting cue for mammalian circadian oscillators

29 September 2017

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Mammalian Per-Arnt-Sim proteins in environmental adaptation

29 September 2017

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29 September 2017

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Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription

29 September 2017

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Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

29 September 2017

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Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment

29 September 2017

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Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior

29 September 2017

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The BMAL1 C terminus regulates the circadian transcription feedback loop.

29 September 2017

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Visualization of molecular interactions by fluorescence complementation

29 September 2017

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PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock

29 September 2017

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Circadian clock control by SUMOylation of BMAL1.

29 September 2017

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Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression

29 September 2017

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29 September 2017

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Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

29 September 2017

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The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules.

29 September 2017

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Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics

2 June 2018

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Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice

2 June 2018

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Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD.

2 June 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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2-Bromo-pyridine-3-carboxylic acid

21 January 2018

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The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription.

21 January 2018

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An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1222804

2 references

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2 February 2020

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2 February 2020

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