Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2 (Q27679465)

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3 February 2020

title

Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2 (English)

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3 February 2020

5

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3 February 2020

Jonathan Javitch

10

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3 February 2020

Jean-Philippe Pin

11

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3 February 2020

author name string

Yong Geng

1

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3 February 2020

Dazhi Xiong

2

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3 February 2020

Lidia Mosyak

3

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3 February 2020

David L Malito

4

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3 February 2020

Yan Chen

6

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3 February 2020

Svetlana Burmakina

7

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3 February 2020

Matthias Quick

8

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3 February 2020

Martin Bush

9

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3 February 2020

Qing R Fan

12

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3 February 2020

language of work or name

English

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publication date

3 June 2012

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3 February 2020

1 reference

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3 February 2020

volume

15

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3 February 2020

issue

7

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3 February 2020

page(s)

970-978

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

3 February 2020

cites work

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20 March 2017

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20 March 2017

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20 March 2017

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

20 March 2017

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Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor

20 March 2017

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Heterodimerization is required for the formation of a functional GABA(B) receptor

20 March 2017

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Structure of a glutamate-receptor ligand-binding core in complex with kainate

20 March 2017

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Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

20 March 2017

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Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Implementation of molecular replacement in AMoRe

20 March 2017

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Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity

20 March 2017

1 reference

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Structural determinants of natriuretic peptide receptor specificity and degeneracy

20 March 2017

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A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor

20 March 2017

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Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

20 March 2017

1 reference

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Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation

20 March 2017

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Protein structure modeling with MODELLER

20 March 2017

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Ligand-induced rearrangements of the GABA(B) receptor revealed by fluorescence resonance energy transfer

7 April 2017

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The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.

29 September 2017

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Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

29 September 2017

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G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

29 September 2017

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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.

29 September 2017

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Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor

29 September 2017

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Monitoring the function of membrane transport proteins in detergent-solubilized form

29 September 2017

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Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

29 September 2017

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Molecular structure and physiological functions of GABA(B) receptors

29 September 2017

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29 September 2017

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29 September 2017

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Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction

29 September 2017

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29 September 2017

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29 September 2017

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No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.

29 September 2017

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29 September 2017

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Ligand-induced signal transduction within heterodimeric GABA(B) receptor

29 September 2017

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Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors

29 September 2017

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A trafficking checkpoint controls GABA(B) receptor heterodimerization

29 September 2017

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Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1.

29 September 2017

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Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding

29 September 2017

1 reference

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Role of heteromer formation in GABAB receptor function

29 September 2017

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GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

29 September 2017

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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

29 September 2017

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29 September 2017

GABAA receptor channels

1 reference

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The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

29 September 2017

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The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNN.3133

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNN.3133

Modelling prior distributions of atoms for macromolecular refinement and completion.

21 January 2018

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Crossref

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Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22660477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22660477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.3133

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22660477%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 February 2020

1014387093

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22660477%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

22660477

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22660477%20AND%20SRC:MED&resulttype=core&format=json