Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent (Q27679795)

1

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Makhtar Niang

2

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Sreekanth Rajan

3

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Peter Rainer Preiser

NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35

4

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language of work or name

English

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publication date

2013

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published in

Scientific Reports

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volume

3

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page(s)

2501

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cites work

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

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NMR assignments of the FK506-binding domain of FK506-binding protein 35 from Plasmodium vivax

20 March 2017

1 reference

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FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53

20 March 2017

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Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506

20 March 2017

1 reference

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Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35)

20 March 2017

1 reference

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The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

20 March 2017

1 reference

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Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis

20 March 2017

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Genome sequence of the human malaria parasite Plasmodium falciparum

20 March 2017

1 reference

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FK506 binding protein associated with the calcium release channel (ryanodine receptor)

20 March 2017

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

20 March 2017

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Phasercrystallographic software

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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The finer things in X-ray diffraction data collection

20 March 2017

2 references

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20 March 2017

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

29 September 2017

1 reference

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Proline isomerization of histone H3 regulates lysine methylation and gene expression

20 March 2017

1 reference

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The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Stereochemistry of polypeptide chain configurations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

20 March 2017

1 reference

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20 March 2017

PMF scoring revisited

1 reference

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Comparison of consensus scoring strategies for evaluating computational models of protein-ligand complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Development and validation of a genetic algorithm for flexible docking

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides

20 March 2017

1 reference

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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

The threat of artemisinin-resistant malaria

24 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Why is Plasmodium vivax a neglected tropical disease?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

FKBP38 protects Bcl-2 from caspase-dependent degradation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Peptidyl-prolyl isomerase inhibitors

29 September 2017

1 reference

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Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

FKBP12 binds to acylated H-ras and promotes depalmitoylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Consensus scoring for ligand/protein interactions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Immunophilins: beyond immunosuppression

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Pharmacophores incorporating numerous excluded volumes defined by X-ray crystallographic structure in three-dimensional database searching: application to the thyroid hormone receptor.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds

2 June 2018

1 reference

Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin.

21 January 2018

1 reference

A bifunctional molecule that displays context-dependent cellular activity

21 January 2018

1 reference

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

21 January 2018

1 reference

Defying malaria: Fathoming severe Plasmodium vivax disease.

21 January 2018

1 reference

LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites

21 January 2018

1 reference

A general and fast scoring function for protein-ligand interactions: a simplified potential approach.

21 January 2018

1 reference

Comparative assessment of scoring functions on a diverse test set.

21 January 2018

1 reference

Supervised consensus scoring for docking and virtual screening.

21 January 2018

1 reference

Comparative evaluation of 11 scoring functions for molecular docking

21 January 2018

1 reference

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752609

Using Fragment Cocktail Crystallography To Assist Inhibitor Design ofTrypanosoma bruceiNucleoside 2-Deoxyribosyltransferase†

27 November 2018

1 reference

12 December 2020

Unbiasing scoring functions: a new normalization and rescoring strategy

1 reference

12 December 2020

Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B)

1 reference

12 December 2020

Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate

1 reference

12 December 2020

Scoring noncovalent protein-ligand interactions: a continuous differentiable function tuned to compute binding affinities

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP02501

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2130494

Dimensions Publication ID

1000466708

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Fatcat ID

release_o5nsoxlcw5eeziag5dpjmsutim

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o5nsoxlcw5eeziag5dpjmsutim

24 November 2022

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

2130494

1 reference