Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex (Q27681271)

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5 February 2020

title

Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex (English)

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5 February 2020

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Erik Martinez-Hackert

2

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5 February 2020

author name string

Sharon A Townson

1

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5 February 2020

Chloe Greppi

3

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5 February 2020

Patricia Lowden

4

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Dianne Sako

5

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5 February 2020

June Liu

6

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Jeffrey A Ucran

7

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Katia Liharska

8

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Kathryn W Underwood

9

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Jasbir Seehra

10

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Ravindra Kumar

11

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Asya V Grinberg

12

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5 February 2020

language of work or name

English

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publication date

20 June 2012

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Journal of Biological Chemistry

5 February 2020

published in

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volume

287

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issue

33

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5 February 2020

page(s)

27313-27325

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Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

5 February 2020

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20 March 2017

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20 March 2017

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20 March 2017

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Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions

20 March 2017

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Crystal structure of the BMP-2-BRIA ectodomain complex

20 March 2017

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Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

20 March 2017

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20 March 2017

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Activation of signalling by the activin receptor complex

20 March 2017

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20 March 2017

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Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

20 March 2017

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20 March 2017

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BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

20 March 2017

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Crystal structure of BMP-9 and functional interactions with pro-region and receptors

20 March 2017

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Bone morphogenetic proteins

20 March 2017

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Mechanism of activation of the TGF-beta receptor

20 March 2017

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A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors

20 March 2017

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Arteriovenous malformations in mice lacking activin receptor-like kinase-1

20 March 2017

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Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line

20 March 2017

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Bioinformatic analysis of pathogenic missense mutations of activin receptor like kinase 1 ectodomain

7 April 2017

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Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth

29 September 2017

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ALK1 as an emerging target for antiangiogenic therapy of cancer

29 September 2017

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Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies

29 September 2017

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ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations

29 September 2017

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2 June 2018

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Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.377960

Gene expression fingerprinting for human hereditary hemorrhagic telangiectasia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22718755

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.377960

2 references

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5 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22718755%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

2 references