Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope (Q27681352)

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English	Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope	scientific article

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5 March 2020

Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design (English)

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5 March 2020

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Beatriz Apellaniz

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Pablo Carravilla

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Igor de la Arada

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Maria Angeles Jimenez

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Steve Bryson

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Soraya Serrano

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Aitziber Araujo

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Nerea Huarte

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Edurne Rujas

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José L R Arrondo

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José L Nieva

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15 January 2014

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5 March 2020

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Journal of Biological Chemistry

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5 March 2020

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5 March 2020

6565-6580

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5 March 2020

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

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20 March 2017

Antibodies in HIV-1 vaccine development and therapy

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20 March 2017

HIV-1 envelope glycoprotein structure

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20 March 2017

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

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20 March 2017

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41

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20 March 2017

Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

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20 March 2017

A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

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20 March 2017

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

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20 March 2017

HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane

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20 March 2017

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

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20 March 2017

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

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20 March 2017

Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion

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20 March 2017

A monomeric 3(10)-helix is formed in water by a 13-residue peptide representing the neutralizing determinant of HIV-1 on gp41

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20 March 2017

The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles

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20 March 2017

Membrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusion

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20 March 2017

Scalable molecular dynamics with NAMD

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20 March 2017

Automated NMR structure calculation with CYANA

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20 March 2017

Protein backbone angle restraints from searching a database for chemical shift and sequence homology

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20 March 2017

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

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20 March 2017

Torsion angle dynamics for NMR structure calculation with the new program DYANA

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20 March 2017

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

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20 March 2017

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20 March 2017

Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein

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20 March 2017

Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicity

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20 March 2017

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

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7 April 2017

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7 April 2017

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

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7 April 2017

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29 September 2017

Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines

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29 September 2017

Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function

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Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

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Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane

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Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

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29 September 2017

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies

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29 September 2017

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant

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Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding

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29 September 2017

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29 September 2017

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29 September 2017

The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

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29 September 2017

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29 September 2017

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29 September 2017

The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.

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29 September 2017

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29 September 2017

Fine definition of the epitope on the gp41 glycoprotein of human immunodeficiency virus type 1 for the neutralizing monoclonal antibody 2F5.

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29 September 2017

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

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29 September 2017

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29 September 2017

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29 September 2017

Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS.

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Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody

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29 September 2017

A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.

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2 June 2018

HIV vaccine design and the neutralizing antibody problem

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21 January 2018

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

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21 January 2018

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

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21 January 2018

Enhancement of alpha -helicity in the HIV-1 inhibitory peptide DP178 leads to an increased affinity for human monoclonal antibody 2F5 but does not elicit neutralizing responses in vitro. Implications for vaccine design

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21 January 2018

Membrane association and epitope recognition by HIV-1 neutralizing anti-gp41 2F5 and 4E10 antibodies.

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21 January 2018

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21 January 2018

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21 January 2018

A molecular mechanics force field for biologically important sterols

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21 January 2018

Interaction of anti-HIV type 1 antibody 2F5 with phospholipid bilayers and its relevance for the mechanism of virus neutralization

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21 January 2018

Site-specific hydration status of an amphipathic peptide in AOT reverse micelles

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21 January 2018

Both lipid environment and pH are critical for determining physiological solution structure of 3-D-conserved epitopes of the HIV-1 gp41-MPER peptide P1.

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21 January 2018

The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring

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21 January 2018

Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan women

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21 January 2018

Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides

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21 January 2018

Infrared amide I' band of the coiled coil

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The conformational analysis of a synthetic S4 peptide corresponding to a voltage-gated potassium ion channel protein

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based on heuristic

inferred from PubMed ID database lookup

Polypeptide secondary structure determination by nuclear magnetic resonance observation of short proton-proton distances

1 reference

https://pubmed.ncbi.nlm.nih.gov/24429284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 vaccine development: constrained peptide immunogens show improved binding to the anti-HIV-1 gp41 MAb

1 reference

https://pubmed.ncbi.nlm.nih.gov/24429284

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(1)H, (13)C and (15)N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

1 reference

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1007/BF00211764

Identifiers

10.1074/JBC.M113.527747

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24429284%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24429284%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24429284%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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