A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA. (Q27681724)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527857%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA (English)

1 reference

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Mycobacterium tuberculosis

8 March 2020

main subject

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author

Cheng-Tsung Lai

2

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8 March 2020

Peter J. Tonge

9

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8 March 2020

author name string

Huei-Jiun Li

1

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8 March 2020

Pan Pan

3

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8 March 2020

Weixuan Yu

4

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8 March 2020

Nina Liu

5

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8 March 2020

Gopal R Bommineni

6

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8 March 2020

Miguel Garcia-Diaz

7

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8 March 2020

Carlos Simmerling

8

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8 March 2020

publication date

10 March 2014

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8 March 2020

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8 March 2020

volume

9

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8 March 2020

issue

4

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8 March 2020

page(s)

986-993

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Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex

8 March 2020

cites work

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A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis

20 March 2017

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20 March 2017

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The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance

20 March 2017

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Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis

20 March 2017

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20 March 2017

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7 April 2017

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7 April 2017

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29 September 2017

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Catalytic efficiency of enzymes: a theoretical analysis

29 September 2017

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Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.

29 September 2017

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29 September 2017

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Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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1 reference

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27 November 2018

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12 December 2020

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12 December 2020

Conformational changes in 2-trans-enoyl-ACP (CoA) reductase (InhA) from M. tuberculosis induced by an inorganic complex: a molecular dynamics simulation study

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1021/CB400896G

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527857%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24527857%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

24527857

1 reference

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