Structure of the AcrAB–TolC multidrug efflux pump (Q27683472)

8

Wah Chiu

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Nathan R James

Nathan R James

3

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Zhao Wang

Zhao Wang

2

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Ben Luisi

9

Ben F Luisi

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author name string

Dijun Du

1

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Jarrod E Voss

4

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Ewa Klimont

5

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Thelma Ohene-Agyei

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

6

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language of work or name

English

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publication date

22 May 2014

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published in

Nature

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volume

509

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issue

7501

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page(s)

512-5

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cites work

1 reference

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Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria

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Structures of sequential open states in a symmetrical opening transition of the TolC exit duct

20 March 2017

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The assembled structure of a complete tripartite bacterial multidrug efflux pump

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Crystal structure of the periplasmic component of a tripartite macrolide-specific efflux pump

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Assembly and Channel Opening in a Bacterial Drug Efflux Machine

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Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist

20 March 2017

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Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

20 March 2017

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Crystal structure of bacterial multidrug efflux transporter AcrB

20 March 2017

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

20 March 2017

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20 March 2017

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Features and development of Coot

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20 March 2017

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Scaling and assessment of data quality

20 March 2017

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Efficient anisotropic refinement of macromolecular structures using FFT

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20 March 2017

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Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

7 April 2017

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Validation of cryo-EM structure of IP₃R1 channel

7 April 2017

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Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump

29 September 2017

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Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

29 September 2017

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Modeling detergent organization around aquaporin-0 using small-angle X-ray scattering

29 September 2017

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29 September 2017

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Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC.

29 September 2017

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29 September 2017

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Structure of reconstituted bacterial membrane efflux pump by cryo-electron tomography.

29 September 2017

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The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC.

29 September 2017

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Identification and characterization of TriABC-OpmH, a triclosan efflux pump of Pseudomonas aeruginosa requiring two membrane fusion proteins

29 September 2017

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A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps

29 September 2017

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Conformational flexibility in the multidrug efflux system protein AcrA.

29 September 2017

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Bridging the information gap: computational tools for intermediate resolution structure interpretation

29 September 2017

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Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4361902

GraFix: sample preparation for single-particle electron cryomicroscopy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4361902

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Linkage of the efflux-pump expression level with substrate extrusion rate in the MexAB-OprM efflux pump of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

Reconstitution of functionally efficient SecA-dependent protein-conducting channels: transformation of low-affinity SecA-liposome channels to high-affinity SecA-SecYEG-SecDF·YajC channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13205

21 January 2018

Identifiers

DOI

10.1038/NATURE13205

1 reference

Dimensions Publication ID

1018733330

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1 reference

1 reference

PubMed publication ID

24747401

1 reference