Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling (Q27683783)

6

0 references

Gregor Witte

object named as

Gregor Witte

5

0 references

author name string

Carina Motz

1

0 references

Kerstin Monika Schuhmann

2

0 references

Axel Kirchhofer

3

0 references

Manuela Moldt

Immune signaling by RIG-I-like receptors

4

0 references

language of work or name

English

0 references

publication date

8 February 2013

0 references

published in

Science

0 references

volume

339

0 references

page(s)

690-3

0 references

issue

6120

0 references

cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

5'-Triphosphate RNA is the ligand for RIG-I

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Activation of MDA5 requires higher-order RNA structures generated during virus infection

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Structural Insights into RNA Recognition by RIG-I

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

The Buccaneer software for automated model building. 1. Tracing protein chains

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

Coot: model-building tools for molecular graphics

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1230949

RIG-I-like receptors: cytoplasmic sensors for non-self RNA.

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Small self-RNA generated by RNase L amplifies antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Viral evasion and subversion of pattern-recognition receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

The N-terminal domain of the phosphoprotein of Morbilliviruses belongs to the natively unfolded class of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

MDA5 assembles into a polar helical filament on dsRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Determination of domain structure of proteins from X-ray solution scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

The RNA binding region of the paramyxovirus SV5 V and P proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

UsingSitusfor the registration of protein structures with low-resolution bead models from X-ray solution scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1230949

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1230949

1 reference

Consolidated OpenCitations Corpus – April 2017

3045606

3045606

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference