Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions (Q27684159)

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Marie Anderson

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Bruce M Bechle

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Brian M Campbell

4

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Cheng Chang

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Amy B Dounay

6

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Edelweiss Evrard

7

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Kari R Fonseca

8

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Xinmin Gan

9

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Somraj Ghosh

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Weldon Horner

11

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Larry C James

12

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Ji-Young Kim

13

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Laura A McAllister

14

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Vinod D Parikh

16

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Brian J Rago

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Michelle A Salafia

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Christine A Strick

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Laura E Zawadzke

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Patrick R Verhoest

ACS Medicinal Chemistry Letters

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publication date

10 January 2013

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published in

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Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior

Crossref

volume

4

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issue

1

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page(s)

37-40

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cites work

1 reference

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Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

20 March 2017

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Structure-guided inhibitor design for human FAAH by interspecies active site conversion

20 March 2017

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The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

20 March 2017

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Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations

20 March 2017

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Cation-pi interactions in structural biology

7 April 2017

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Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

7 April 2017

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Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

29 September 2017

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Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder

29 September 2017

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Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders

29 September 2017

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Increased cortical kynurenate content in schizophrenia

29 September 2017

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Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia

2 June 2018

1 reference

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Cation-pi interactions in protein-protein interfaces

27 November 2018

1 reference

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Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia

27 November 2018

1 reference

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Characterization of human brain kynurenine aminotransferases using [3H]kynurenine as a substrate

27 November 2018

1 reference

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Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900560

12 December 2020

inferred from PubMed ID database lookup

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900560

12 December 2020

inferred from PubMed ID database lookup

Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900560

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/ML300237V

1 reference

release_luaqdz2j45hiljaevq2b5anw44

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/luaqdz2j45hiljaevq2b5anw44

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

24900560

1 reference