Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function (Q27687684)

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English	Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function	scientific article

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1 March 2020

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function (English)

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1 March 2020

Caenorhabditis elegans

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1 March 2020

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1 March 2020

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1 March 2020

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Su Ling Leong

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1 March 2020

Kevin J Barnham

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1 March 2020

Anthony G Wedd

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1 January 2014

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1 March 2020

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1 March 2020

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1 March 2020

105-116

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1 March 2020

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

The beta A4 amyloid precursor protein binding to copper.

1 reference

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21 January 2018

Causes of oxidative stress in Alzheimer disease.

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21 January 2018

Copper and oxidative stress in the pathogenesis of Alzheimer's disease

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21 January 2018

What the evolution of the amyloid protein precursor supergene family tells us about its function

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21 January 2018

The APP family of proteins: similarities and differences

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21 January 2018

The amyloid-beta precursor protein: integrating structure with biological function

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21 January 2018

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

1 reference

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21 January 2018

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

1 reference

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21 January 2018

Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Regulation of neuronal APL-1 expression by cholesterol starvation

1 reference

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21 January 2018

Caenorhabditis elegans as a model organism to study APP function

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Intracellular Trafficking and Synaptic Function of APL-1 in Caenorhabditis elegans

1 reference

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21 January 2018

APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development

1 reference

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21 January 2018

Structural Characterization of the E2 Domain of APL-1, a Caenorhabditis elegans Homolog of Human Amyloid Precursor Protein, and Its Heparin Binding Site

1 reference

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21 January 2018

Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Expression of human amyloid precursor protein ectodomains in Pichia pastoris: analysis of culture conditions, purification, and characterization

1 reference

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21 January 2018

High-level secretion and very efficient isotopic labeling of tick anticoagulant peptide (TAP) expressed in the methylotrophic yeast, Pichia pastoris

1 reference

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21 January 2018

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

Multiple sequence alignment with the Clustal series of programs

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

1 reference

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21 January 2018

The program XEASY for computer-supported NMR spectral analysis of biological macromolecules

1 reference

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21 January 2018

Protein backbone angle restraints from searching a database for chemical shift and sequence homology

1 reference

https://api.crossref.org/works/10.1039%2FC3MT00258F

21 January 2018

The Xplor-NIH NMR molecular structure determination package

1 reference

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21 January 2018

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

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21 January 2018

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation

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21 January 2018

Roll: a new algorithm for the detection of protein pockets and cavities with a rolling probe sphere.

1 reference

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21 January 2018

Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidase.

1 reference

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21 January 2018

The challenges of determining metal-protein affinities

1 reference

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21 January 2018

Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolar

1 reference

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21 January 2018

Enhanced superoxide and hydrogen peroxide detection in biological assays

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21 January 2018

Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form

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21 January 2018

Calorimetric investigation of copper(II) binding to Aβ peptides: thermodynamics of coordination plasticity

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21 January 2018

Cu(II) affinity for the Alzheimer's peptide: tyrosine fluorescence studies revisited.

1 reference

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21 January 2018

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

1 reference

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21 January 2018

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

1 reference

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21 January 2018

Modeling the Cu+ binding in the 1-16 region of the amyloid-β peptide involved in Alzheimer's disease.

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21 January 2018

Modeling copper binding to the amyloid-β peptide at different pH: toward a molecular mechanism for Cu reduction.

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21 January 2018

Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers

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21 January 2018

Ascorbate regulation and its neuroprotective role in the brain

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21 January 2018

The Rich Electrochemistry and Redox Reactions of the Copper Sites in the Cellular Prion Protein

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Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

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