A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis (Q27698131)

Mycobacterium smegmatis

1 reference

5

Edouard Tuaillon

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Mickael Blaise

Mickael Blaise

2

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Yann Guérardel

Yann Guérardel

8

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Michel Drancourt

9

Michel Drancourt

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Laurent Kremer

12

Laurent Kremer

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author name string

Séverine Carrère-Kremer

1

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Vipul K Singh

3

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Laeticia Alibaud

4

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Iman Halloum

6

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Robert van de Weerd

7

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Howard Takiff

10

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Jeroen Geurtsen

PHENIX: a comprehensive Python-based system for macromolecular structure solution

11

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language of work or name

English

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publication date

June 2015

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published in

Molecular Microbiology

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volume

96

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issue

5

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page(s)

1085-102

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cites work

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Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria

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Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis

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Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study

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Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

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Surviving within the amoebal exocyst: the Mycobacterium avium complex paradigm

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In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system.

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Crystal structure of dehydratase component HadAB complex of mycobacterial FAS-II pathway

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Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex

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Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

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The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes

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Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block

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Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues

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Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathway

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Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

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EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets

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Looking in amoebae as a source of mycobacteria

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Features and development of Coot

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Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis

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A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis

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An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases

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A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone

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Dali server: conservation mapping in 3D

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Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria

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Integration, scaling, space-group assignment and post-refinement

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Conserved mechanisms of Mycobacterium marinum pathogenesis within the environmental amoeba Acanthamoeba castellanii

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Recombineering in Mycobacterium tuberculosis.

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Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2

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A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2.

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Acanthamoeba polyphaga-enhanced growth of Mycobacterium smegmatis

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The genealogic tree of mycobacteria reveals a long-standing sympatric life into free-living protozoa

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Accurate molecular mass determination of mycolic acids by MALDI-TOF mass spectrometry

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A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates

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Phasercrystallographic software

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Genome analyses highlight the different biological roles of cellulases

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Mycobacterium abscessus: a new antibiotic nightmare

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Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule

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Knock-down of a member of the isoflavone reductase gene family impairs plant growth and nodulation in Phaseolus vulgaris

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Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo

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The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis

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Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis

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Preclinical pharmacokinetics of KBF611, a new antituberculosis agent in mice and rabbits, and comparison with thiacetazone

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Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard

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The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions

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1 reference

A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis.

21 January 2018

1 reference

The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis

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21 January 2018

Identifiers

DOI

10.1111/MMI.12992

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

25754266

1 reference

Consolidated OpenCitations Corpus – April 2017