The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity (Q27728076)

5

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author name string

Cynthia M June

1

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Taylor J Muckenthaler

2

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Emma C Schroder

3

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Zachary L Klamer

4

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Rachel A Powers

6

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Agnieszka Szarecka

7

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David A Leonard

Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

8

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language of work or name

1 reference

16 September 2016

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published in

Protein Science

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cites work

1 reference

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Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam

20 March 2017

1 reference

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Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein design

20 March 2017

1 reference

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Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

1 reference

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The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem

20 March 2017

1 reference

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Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

20 March 2017

1 reference

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Phasercrystallographic software

20 March 2017

1 reference

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CHARMM: the biomolecular simulation program

20 March 2017

1 reference

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Protein structure prediction on the Web: a case study using the Phyre server

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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Calculation of protein extinction coefficients from amino acid sequence data

20 March 2017

1 reference

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Class D β-lactamases: a reappraisal after five decades

20 March 2017

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

20 March 2017

1 reference

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Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems

7 April 2017

1 reference

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Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases

29 September 2017

1 reference

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Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119573

Evolution of carbapenem-resistant Acinetobacter baumannii revealed through whole-genome sequencing and comparative genomic analysis

29 September 2017

1 reference

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29 September 2017

1 reference

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Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities

29 September 2017

1 reference

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The rise of carbapenem-resistant Acinetobacter baumannii

29 September 2017

1 reference

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Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan

29 September 2017

1 reference

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Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119573

An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii

29 September 2017

1 reference

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MMTSB Tool Set: enhanced sampling and multiscale modeling methods for applications in structural biology.

29 September 2017

1 reference

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Extensively drug-resistant Acinetobacter baumannii

29 September 2017

1 reference

The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii.

21 January 2018

1 reference

Common clinical substitutions enhance the carbapenemase activity of OXA-51-like class D β-lactamases from Acinetobacter spp.

21 January 2018

1 reference

Conversion of OXA-66 into OXA-82 in clinical Acinetobacter baumannii isolates and association with altered carbapenem susceptibility

21 January 2018

1 reference

First identification of blaOXA-51-like in non-baumannii Acinetobacter spp.

21 January 2018

1 reference

Eleven novel OXA-51-like enzymes from clinical isolates of Acinetobacter baumannii.

21 January 2018

1 reference

OXA-51-like beta-lactamases and their association with particular epidemic lineages of Acinetobacter baumannii

21 January 2018

1 reference

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

Outer membrane permeability of Acinetobacter calcoaceticus and its implication in antibiotic resistance

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27636561

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

bla(OXA-51)-type beta-lactamase genes are ubiquitous and vary within a strain in Acinetobacter baumannii

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27636561