Structure and mechanism of interleukin-1 beta converting enzyme (Q27730830)

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J A Thomson

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E E Kim

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J P Griffith

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M A Navia

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M A Murcko

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S P Chambers

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R A Aldape

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S A Raybuck

Activation of interleukin-1 beta by a co-induced protease

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language of work or name

English

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publication date

28 July 1994

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published in

Nature

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volume

370

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issue

6487

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page(s)

270-5

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cites work

1 reference

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Identification of a monocyte specific pre-interleukin 1 beta convertase activity

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Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

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Interleukin 1 beta is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human monocytes

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

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Molecular cloning of the interleukin-1 beta converting enzyme

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme

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Prevention of vertebrate neuronal death by the crmA gene

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Cell death studies yield cancer clues

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The IL-1 beta converting enzyme as a therapeutic target.

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On the mode of activation of the catalytically essential sulfhydryl group of papain

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Contribution of the glutamine 19 side chain to transition-state stabilization in the oxyanion hole of papain

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Importance of hydrogen-bonding interactions involving the side chain of Asp158 in the catalytic mechanism of papain

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The accessible surface area and stability of oligomeric proteins

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Role of interleukin-1 in infectious diseases

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Rheumatoid arthritis. Pathophysiology and implications for therapy

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Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus

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Interleukin-1 receptor antagonist in normal and psoriatic epidermis

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In situ production of TNF-alpha, IL-1 beta and IL-2R in ANCA-positive glomerulonephritis

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Anticytokine strategies in the treatment of the systemic inflammatory response syndrome

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Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

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The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice

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Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

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Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

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Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution

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