Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450 (Q27733420)

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English	Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450	scientific article

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scholarly article

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Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450 (English)

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crystal structure

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pharmacokinetics

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based on heuristic

inferred from title

author name string

C N Hodge

1

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P E Aldrich

2

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L T Bacheler

3

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C H Chang

4

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C J Eyermann

5

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S Garber

6

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M Grubb

7

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D A Jackson

8

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P K Jadhav

9

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B Korant

10

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P Y Lam

11

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M B Maurin

12

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J L Meek

13

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M J Otto

14

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M M Rayner

15

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C Reid

16

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T R Sharpe

17

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L Shum

18

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D L Winslow

19

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S Erickson-Viitanen

20

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language of work or name

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publication date

April 1996

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Chemistry and Biology

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3

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4

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301-14

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Structure-based inhibitors of HIV-1 protease

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7 January 2021

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Recent advances in the design of HIV proteinase inhibitors

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https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

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Progress in anti-HIV structure-based drug design

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inferred from DOI database lookup

Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity.

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A C2 symmetry-based HIV protease inhibitor, A77003, irreversibly inhibits infectivity of HIV-1 in vitro

1 reference

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The HIV-1 protease as a therapeutic target for AIDS

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7 January 2021

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The retroviral enzymes

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based on heuristic

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Rational design of peptide-based HIV proteinase inhibitors

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7 January 2021

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inferred from DOI database lookup

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

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7 January 2021

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Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors

1 reference

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7 January 2021

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A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group

1 reference

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7 January 2021

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Weak binding of VX-478 to human plasma proteins and implications for anti-human immunodeficiency virus therapy

1 reference

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7 January 2021

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Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors

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https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

based on heuristic

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A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs

1 reference

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7 January 2021

based on heuristic

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Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323

1 reference

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7 January 2021

based on heuristic

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In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

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DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

based on heuristic

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Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323

1 reference

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7 January 2021

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Limited sequence diversity of the HIV type 1 protease gene from clinical isolates and in vitro susceptibility to HIV protease inhibitors

1 reference

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based on heuristic

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Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

based on heuristic

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A symmetric inhibitor binds HIV-1 protease asymmetrically

1 reference

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7 January 2021

based on heuristic

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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

based on heuristic

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Viral dynamics in human immunodeficiency virus type 1 infection

1 reference

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7 January 2021

based on heuristic

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HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

1 reference

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7 January 2021

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inferred from DOI database lookup

Safety and activity of saquinavir in HIV infection

1 reference

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based on heuristic

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Analysis of non-infectious HIV particles produced in presence of HIV proteinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2896%2990110-6

7 January 2021

based on heuristic

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SC-52151, a novel inhibitor of the human immunodeficiency virus protease

1 reference

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7 January 2021

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Direct gene transfer into mouse muscle in vivo

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7 January 2021

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A novel isolation method of a stable crystalline salt of a cyclic RGD peptide zwitterion

1 reference

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7 January 2021

based on heuristic

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Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates.

1 reference

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Construction of infectious molecular clones of HIV-1 containing defined mutations in the protease gene

1 reference

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7 January 2021

based on heuristic

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Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease

1 reference

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7 January 2021

based on heuristic

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Crystallographic R factor refinement by molecular dynamics

1 reference

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1 reference

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Identifiers

10.1016/S1074-5521(96)90110-6

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release_tm6xvl2vljavblyu4324f7sjli

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https://api.fatcat.wiki/v0/release/tm6xvl2vljavblyu4324f7sjli

24 November 2022

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