Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2 (Q27734731)

2

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E J Gray

3

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W Leupin

4

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S Neidle

Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin

5

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language of work or name

English

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publication date

15 December 1996

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published in

Nucleic Acids Research

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volume

24

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issue

24

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page(s)

4882-9

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cites work

1 reference

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Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine

20 March 2017

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Sequence-Dependent Drug Binding to the Minor Groove of DNA: Crystal Structure of the DNA Dodecamer d(CGCAAATTTGCG)2 Complexed with Propamidine

20 March 2017

1 reference

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Three-dimensional crystal structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor-groove-binding drug Hoechst 33258

20 March 2017

1 reference

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Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex

20 March 2017

1 reference

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Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2

20 March 2017

1 reference

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A bifurcated hydrogen-bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin

20 March 2017

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Re-refinement of the B-dodecamer d(CGCGAATTCGCG) with a comparative analysis of the solvent in it and in the Z-hexamer d(5BrCG5BrCG5BrCG)

20 March 2017

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Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G

20 March 2017

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The molecular structure of the complex of Hoechst 33258 and the DNA dodecamer d(CGCGAATTCGCG)

20 March 2017

1 reference

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Binding of Hoechst 33258 to the minor groove of B-DNA

20 March 2017

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Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding

20 March 2017

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Low-temperature crystallographic analyses of the binding of Hoechst 33258 to the double-helical DNA dodecamer C-G-C-G-A-A-T-T-C-G-C-G

20 March 2017

1 reference

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Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342

20 March 2017

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Crystallographic R factor refinement by molecular dynamics

20 March 2017

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Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia

20 March 2017

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The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids

20 March 2017

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Determination of the NMR solution structure of the Hoechst 33258-d(GTGGAATTCCAC)2 complex and comparison with the X-ray crystal structure

7 April 2017

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NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2.

29 September 2017

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Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA.

29 September 2017

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Targeting DNA-binding drugs to sequence-specific transcription factor.DNA complexes. Differential effects of intercalating and minor groove binding drugs.

29 September 2017

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Dicationic diarylfurans as anti-Pneumocystis carinii agents

29 September 2017

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DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

29 September 2017

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Interaction of Hoechst 33258 with the minor groove of the A + T-rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy

29 September 2017

1 reference

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Synthesis, DNA binding, footprinting and in vitro antitumour studies of a meta-hydroxy analogue of Hoechst 33258.

29 September 2017

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DNA-directed alkylating agents. 6. Synthesis and antitumor activity of DNA minor groove-targeted aniline mustard analogues of pibenzimol (Hoechst 33258)

29 September 2017

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Molecular design of DNA-directed ligands with specific interactions: solution NMR studies of the interaction of a m-hydroxy analogue of Hoechst 33258 with d(CGCGAATTCGCG)2.

29 September 2017

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Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA.

29 September 2017

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Binding of a Hoechst dye to d(CGCGATATCGCG) and its influence on the conformation of the DNA fragment

29 September 2017

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Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material

29 September 2017

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Design of sequence-specific DNA-binding molecules

29 September 2017

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Dynamics and binding mode of Hoechst 33258 to d(GTGGAATTCCAC)2 in the 1:1 solution complex as determined by two-dimensional 1H NMR.

29 September 2017

1 reference

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Molecular recognition between ligands and nucleic acids: novel pyridine- and benzoxazole-containing agents related to Hoechst 33258 that exhibit altered DNA sequence specificity deduced from footprinting analysis and spectroscopic studies

29 September 2017

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Sequence Specific Molecular Recognition and Binding by a GC Recognizing Hoechst 33258 Analogue to the Decadeoxyribonucleotide d-[CATGGCCATG]2: Structural and Dynamic Aspects Deduced from High Field1H-NMR Studies

29 September 2017

1 reference

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Sequence-specific interaction of Hoescht 33258 with the minor grooVe of an adenine-tract DNA duplex studied in solution by1H NMR spectroscopy

29 September 2017

1 reference

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Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties

29 September 2017

1 reference

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Minor-groove width and accessibility in B-DNA drug and protein complexes

29 September 2017

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Effects of analogs of the DNA minor groove binder Hoechst 33258 on topoisomerase II and I mediated activities

29 September 2017

1 reference

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Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin

29 September 2017

1 reference

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Synthesis and anti-tumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-[N,N-dimethylamino)methy l)-aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor groove

29 September 2017

1 reference

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Selective DNA interaction of the novel distamycin derivative FCE 24517.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146347

Structure and DNA binding activity of analogs of 1,5-bis(4-amidinophenoxy)pentane (pentamidine)

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146347

Distamycin-induced inhibition of homeodomain-DNA complexes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=146347

Molecular recognition between oligopeptides and nucleic acids: DNA sequence specificity and binding properties of thiazole-lexitropsins incorporating the concepts of base site acceptance and avoidance

2 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9017011

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular struggle for transcriptional control

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9017011

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/24.24.4882

0 references

Fatcat ID

release_miu7ceptmfaldghgrfavelf3um

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/miu7ceptmfaldghgrfavelf3um