Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation (Q27739531)

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I J Clifton

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C M Hensgens

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C J Schofield

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J Hajdu

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J E Baldwin

The biosynthesis of penicillins and cephalosporins

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language of work or name

English

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publication date

19 June 1997

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published in

Nature

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volume

387

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page(s)

827-30

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issue

6635

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cites work

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Purification of isopenicillin N synthetase

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Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites

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Thiolate ligation of the active site Fe2+ of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys----Ser mutated enzymes

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Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

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Ferrous active site of isopenicillin N synthase: genetic and sequence analysis of the endogenous ligands

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The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function

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A stereochemical concept for the catalytic mechanism of prolylhydroxylase: applicability to classification and design of inhibitors.

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Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad

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Three-dimensional structures of free form and two substrate complexes of an extradiol ring-cleavage type dioxygenase, the BphC enzyme from Pseudomonas sp. strain KKS102

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X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes

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Anaerobic Crystallisation of an Isopenicillin N Synthase . Fe(II) . Substrate Complex Demonstrated by X-Ray Studies

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Electron transport in cytochromes P-450 by covalent switching

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X-ray absorption spectroscopic studies of the Fe(II) active site of catechol 2,3-dioxygenase. Implications for the extradiol cleavage mechanism

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Penicillin biosynthesis: active site mapping with aminoadipoylcysteinylvaline variants

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inferred from DOI database lookup

7 January 2021

based on heuristic

Evidence for an insertion-homolysis mechanism for carbon-sulphur bond formation in penicillin biosynthesis; 2. Incubation and interpretation

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