Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA (Q27748801)

2

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L Thomas

3

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P F Alewood

4

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R J Lewis

5

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D J Craik

The charybdotoxin family of K+ channel-blocking peptides

6

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publication date

15 December 1997

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published in

Structure

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volume

5

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issue

12

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page(s)

1585-97

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cites work

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Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

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Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

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Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations

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Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin

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Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis

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Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis

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Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels

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Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry

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A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202

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Strategy for rapid immobilization of prey by a fish-hunting marine snail

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Determination of the subunit stoichiometry of a voltage-activated potassium channel

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1990: annus mirabilis of potassium channels

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Voltage gating of ion channels

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Pore loops: an emerging theme in ion channel structure

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Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

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An essential binding surface for ShK toxin interaction with rat brain potassium channels

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Mechanism of charybdotoxin block of a voltage-gated K+ channel.

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

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Competition for block of a Ca2(+)-activated K+ channel by charybdotoxin and tetraethylammonium

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A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

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Snail and spider toxins share a similar tertiary structure and 'cystine motif'

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The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider

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7 January 2021

A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.

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Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin.

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The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition.

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Electrostatic distance geometry in a K+ channel vestibule

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In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences

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Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.

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Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

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A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

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Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2.

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7 January 2021

Biophysical and molecular mechanisms of Shaker potassium channel inactivation

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A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel.

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7 January 2021