MEK1 mutations confer resistance to MEK and B-RAF inhibition (Q27777362)

16

object named as

Levi A Garraway

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Nathanael Gray

13

object named as

Nathanael S Gray

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author name string

Caroline M Emery

1

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Krishna G Vijayendran

2

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Marie C Zipser

3

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Allison M Sawyer

4

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Lili Niu

5

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Jessica J Kim

6

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Charles Hatton

7

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Rajiv Chopra

8

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Patrick A Oberholzer

9

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Maria B Karpova

10

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Laura E MacConaill

11

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Jianming Zhang

12

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William R Sellers

Proceedings of the National Academy of Sciences of the United States of America

14

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language of work or name

English

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publication date

1 December 2009

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published in

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volume

106

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page(s)

20411-6

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issue

48

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cites work

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

1 reference

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Accurate whole human genome sequencing using reversible terminator chemistry

20 March 2017

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

20 March 2017

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

20 March 2017

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Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

20 March 2017

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Mutations of the BRAF gene in human cancer

20 March 2017

1 reference

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Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

20 March 2017

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

20 March 2017

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BRAF mutation predicts sensitivity to MEK inhibition

20 March 2017

1 reference

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

7 April 2017

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

7 April 2017

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(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

7 April 2017

1 reference

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Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777185

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

29 September 2017

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Modeling genomic diversity and tumor dependency in malignant melanoma

29 September 2017

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Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

29 September 2017

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Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy

29 September 2017

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Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.

29 September 2017

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

29 September 2017

1 reference

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Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

29 September 2017

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CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

29 September 2017

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Cell signaling and cancer

29 September 2017

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Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.

29 September 2017

1 reference

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Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group

29 September 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905833106

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905833106

Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905833106

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905833106

High-throughput oncogene mutation profiling in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905833106

21 January 2018

Identifiers

DOI

10.1073/PNAS.0905833106

1 reference

release_e4hvjcspdnaulldln4ppcg22pm

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e4hvjcspdnaulldln4ppcg22pm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1503785

1 reference

1 reference

1 reference