Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers (Q27851457)

21

Kwok-Kin Wong

0 references

Lewis C. Cantley

Lewis C Cantley

20

0 references

Umar Mahmood

19

Umar Mahmood

0 references

Rabi Upadhyay

6

Rabi Upadhyay

0 references

author name string

Jeffrey A Engelman

1

0 references

Liang Chen

2

0 references

Xiaohong Tan

3

0 references

Katherine Crosby

4

0 references

Alexander R Guimaraes

5

0 references

Michel Maira

7

0 references

Kate McNamara

8

0 references

Samanthi A Perera

9

0 references

Youngchul Song

10

0 references

Lucian R Chirieac

11

0 references

Ramneet Kaur

12

0 references

Angela Lightbown

13

0 references

Jessica Simendinger

14

0 references

Timothy Li

15

0 references

Robert F Padera

16

0 references

Carlos García-Echeverría

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

17

0 references

language of work or name

English

0 references

publication date

December 2008

0 references

published in

Nature Medicine

0 references

volume

14

0 references

issue

12

0 references

page(s)

1351-6

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683415

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

20 March 2017

1 reference

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

20 March 2017

1 reference

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

20 March 2017

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

20 March 2017

1 reference

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

20 March 2017

1 reference

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

20 March 2017

1 reference

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

20 March 2017

1 reference

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PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab

7 April 2017

1 reference

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The role of phosphoinositide 3-kinase pathway inhibitors in the treatment of lung cancer

29 September 2017

1 reference

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Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy

29 September 2017

1 reference

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683415

"Oncogenic shock": explaining oncogene addiction through differential signal attenuation

29 September 2017

1 reference

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

29 September 2017

1 reference

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Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase

29 September 2017

1 reference

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Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683415

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683415

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683415

Conditional gene expression in the respiratory epithelium of the mouse.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683415

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

27 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.1890

inferred from DOI database lookup

7 January 2021

based on heuristic

Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.1890

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM.1890

1 reference

Dimensions Publication ID

867342

1000532983

0 references

867342

1 reference

1 reference

1 reference