Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model (Q27851780)

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30 January 2020

title

Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model (English)

2 references

13 November 2016

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30 January 2020

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1 reference

5

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30 January 2020

author name string

Michelle J Lee

1

1 reference

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30 January 2020

Beryl A Hatton

2

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30 January 2020

Elisabeth H Villavicencio

3

1 reference

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30 January 2020

Paritosh C Khanna

4

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30 January 2020

Sally Ditzler

6

1 reference

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30 January 2020

Barbara Pullar

7

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30 January 2020

Keith Robison

8

1 reference

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30 January 2020

Kerry F White

9

1 reference

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30 January 2020

Chris Tunkey

10

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30 January 2020

Michael LeBlanc

11

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30 January 2020

Julie Randolph-Habecker

12

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30 January 2020

Sue E Knoblaugh

13

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Stacey Hansen

14

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30 January 2020

Andrew Richards

15

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30 January 2020

Brandon J Wainwright

16

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30 January 2020

Karen McGovern

17

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30 January 2020

James M Olson

18

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30 January 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

30 January 2020

published in

1 reference

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volume

109

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issue

20

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30 January 2020

page(s)

7859-7864

1 reference

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

30 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

20 March 2017

1 reference

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Patched1 functions as a gatekeeper by promoting cell cycle progression

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

An animal model of MYC-driven medulloblastoma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Medulloblastoma comprises four distinct molecular variants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

29 September 2017

1 reference

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Medulloblastoma: from molecular pathology to therapy

29 September 2017

1 reference

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Drug resistance in brain diseases and the role of drug efflux transporters.

29 September 2017

1 reference

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356655

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1114718109

21 January 2018

Identifiers

DOI

10.1073/PNAS.1114718109

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22550175%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

ADS bibcode

2012PNAS..109.7859L

0 references

1 reference

2 references

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30 January 2020

2 references

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