Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. (Q27851940)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

Cyclin-dependent kinase 6

15 February 2020

main subject

cell biology

0 references

1 reference

GOA release 2020-03-11

Cyclin D3

1 reference

GOA release 2020-03-11

1 reference

1

1 reference

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15 February 2020

Eulàlia Genescà

7

1 reference

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15 February 2020

13

Iannis Aifantis

1 reference

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15 February 2020

author name string

Jacquelyn Freund

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Philmo Oh

3

1 reference

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15 February 2020

Delphine Ndiaye-Lobry

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Jamieson C Bretz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Alexandros Strikoudis

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Thomas Trimarchi

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Michelle A Kelliher

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Marcus Clark

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Jean Soulier

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Selina Chen-Kiang

12

1 reference

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15 February 2020

publication date

1 October 2012

1 reference

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15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

22

1 reference

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15 February 2020

issue

4

1 reference

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15 February 2020

page(s)

452-465

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

15 February 2020

cites work

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Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

20 March 2017

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

20 March 2017

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

20 March 2017

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

20 March 2017

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

20 March 2017

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

7 April 2017

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

7 April 2017

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

7 April 2017

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Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1).

7 April 2017

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Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

29 September 2017

1 reference

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The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

29 September 2017

1 reference

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Requirement for cyclin D3 in germinal center formation and function.

29 September 2017

1 reference

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Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

29 September 2017

1 reference

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

29 September 2017

1 reference

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Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

29 September 2017

1 reference

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Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

29 September 2017

1 reference

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Molecular pathogenesis of T-cell leukaemia and lymphoma

29 September 2017

1 reference

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

29 September 2017

1 reference

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Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

29 September 2017

1 reference

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Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes

29 September 2017

1 reference

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Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.

29 September 2017

1 reference

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A unique function for cyclin D3 in early B cell development

29 September 2017

1 reference

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Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1

29 September 2017

1 reference

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Activating Notch1 mutations in mouse models of T-ALL.

29 September 2017

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Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

29 September 2017

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Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation.

29 September 2017

1 reference

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Genetic replacement of cyclin D1 function in mouse development by cyclin D2.

29 September 2017

1 reference

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Living with or without cyclins and cyclin-dependent kinases

29 September 2017

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

29 September 2017

1 reference

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Development of mice expressing a single D-type cyclin.

29 September 2017

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

29 September 2017

1 reference

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Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

29 September 2017

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

29 September 2017

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29 September 2017

Cyclin D and oncogenesis

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29 September 2017

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Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

29 September 2017

1 reference

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

2 June 2018

1 reference

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p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493168

Differential regulation of cyclin D1 and D2 in protecting against cardiomyocyte proliferation

27 November 2018

1 reference

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A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model.

27 November 2018

1 reference

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A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

27 November 2018

1 reference

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Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493168

Mouse development and cell proliferation in the absence of D-cyclins.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3493168

Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23079656

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential phosphorylation of T-47D human breast cancer cell substrates by D1-, D3-, E-, and A-type cyclin-CDK complexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23079656

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23079656

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2012.09.016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

2 references

13 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

2 references

13 November 2016

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23079656%20AND%20SRC:MED&resulttype=core&format=json