Activating ESR1 mutations in hormone-resistant metastatic breast cancer (Q27852630)

Shanker Kalyana-Sundaram

7

0 references

Kenneth J. Pienta

15

Kenneth J Pienta

0 references

James M Rae

18

James M Rae

0 references

Scott A Tomlins

13

Scott A Tomlins

0 references

Lakshmi P Kunju

22

Lakshmi P Kunju

0 references

Xuhong Cao

6

Xuhong Cao

0 references

Pankaj Vats

3

Pankaj Vats

0 references

Robert J Lonigro

5

Robert J Lonigro

0 references

author name string

Dan R Robinson

1

0 references

Yi-Mi Wu

2

0 references

Fengyun Su

4

0 references

Rui Wang

8

0 references

Yu Ning

9

0 references

Lynda Hodges

10

0 references

Amy Gursky

11

0 references

Javed Siddiqui

12

0 references

Sameek Roychowdhury

14

0 references

Scott Y Kim

16

0 references

J Scott Roberts

17

0 references

Catherine H Van Poznak

19

0 references

Daniel F Hayes

20

0 references

Rashmi Chugh

21

0 references

Moshe Talpaz

23

0 references

Anne F Schott

24

0 references

Arul M Chinnaiyan

A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.

25

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language of work or name

English

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publication date

December 2013

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published in

Nature Genetics

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volume

45

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issue

12

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page(s)

1446-51

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cites work

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

20 March 2017

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The Sequence Alignment/Map format and SAMtools

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Integrated genomic characterization of endometrial carcinoma

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Whole-genome analysis informs breast cancer response to aromatase inhibition

20 March 2017

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PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

20 March 2017

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Circulating mutant DNA to assess tumor dynamics

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Estrogen Receptors as Therapeutic Targets in Breast Cancer

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22 April 2017

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Analysis of circulating tumor DNA to monitor metastatic breast cancer

7 April 2017

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Diverse somatic mutation patterns and pathway alterations in human cancers

7 April 2017

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

7 April 2017

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Advances in understanding cancer genomes through second-generation sequencing

7 April 2017

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An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

22 April 2017

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Aromatase inhibition 2013: clinical state of the art and questions that remain to be solved

29 September 2017

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Personalized oncology through integrative high-throughput sequencing: a pilot study

29 September 2017

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Detection of somatic copy number alterations in cancer using targeted exome capture sequencing

29 September 2017

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Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

29 September 2017

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Mechanisms of endocrine resistance in breast cancer

29 September 2017

1 reference

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Estrogen receptor mutations and changes in downstream gene expression and signaling

29 September 2017

1 reference

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Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study

29 September 2017

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Low-dose estrogen therapy to reverse acquired antihormonal resistance in the treatment of breast cancer

29 September 2017

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Pathways to tamoxifen resistance

29 September 2017

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Estrogen receptors as therapeutic targets in breast cancer

29 September 2017

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Modulation of estrogen receptor alpha function and stability by tamoxifen and a critical amino acid (Asp-538) in helix 12.

29 September 2017

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Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists

29 September 2017

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Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

29 September 2017

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Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.

29 September 2017

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Mutation of Leu-536 in Human Estrogen Receptor-α Alters the Coupling between Ligand Binding, Transcription Activation, and Receptor Conformation

29 September 2017

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Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction.

2 June 2018

1 reference

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Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.

2 June 2018

1 reference

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Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032.

19 June 2018

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Cancer genomics: from discovery science to personalized medicine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24185510

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Formation of a powerful capping motif corresponding to start of "helix 12" in agonist-bound estrogen receptor-alpha contributes to increased constitutive activity of the protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24185510

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.2823

1 reference

Dimensions Publication ID

268017

1010741940

0 references

268017

1 reference

1 reference

1 reference