A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition (Q27852692)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265152%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition (English)

2 references

13 November 2016

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1 March 2020

11

1 reference

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1 March 2020

Richard F. Kefford

12

1 reference

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1 March 2020

Georgina V. Long

14

1 reference

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13

Antoni Ribas

1 reference

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1 March 2020

3

Xiangju Kong

1 reference

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1 March 2020

1

Hubing Shi

1 reference

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1 March 2020

2

Aayoung Hong

1 reference

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1 March 2020

4

Richard C Koya

1 reference

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1 March 2020

6

Gatien Moriceau

1 reference

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1 March 2020

7

Willy Hugo

1 reference

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1 March 2020

10

Thinle Chodon

1 reference

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1 March 2020

author name string

Chunying Song

5

1 reference

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1 March 2020

Clarissa C Yu

8

1 reference

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1 March 2020

Charles Ng

9

1 reference

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1 March 2020

Roger S Lo

15

1 reference

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1 March 2020

publication date

21 November 2013

1 reference

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1 March 2020

2 references

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1 March 2020

volume

4

1 reference

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1 March 2020

issue

1

1 reference

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1 March 2020

page(s)

69-79

1 reference

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Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma

1 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

A landscape of driver mutations in melanoma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

20 March 2017

https://pubmed.ncbi.nlm.nih.gov/24265152

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutations of the BRAF gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Novel somatic mutations to PI3K pathway genes in metastatic melanoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Receptor tyrosine kinases in cancer escape from BRAF inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Combinatorial therapies to overcome B-RAF inhibitor resistance in melanomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

Meeting report from the Society for Melanoma Research 2012 Congress, Hollywood, California.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893054

10.1158/2159-8290.CD-13-0279

27 November 2018

Identifiers

DOI

2 references

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1 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24265152%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2 references